Biosensors based on cantilevers

Alvarez, Mar, Carrascosa, Laura G., Zinoviev, Kiril, Plaza, J.ose A. and Lechuga, Laura M. (2009). Biosensors based on cantilevers. In Rasooly, Avraham and Herold, Keith E. (Ed.), Biosensors and biodetection : methods and protocols (pp. 51-71) New York , NY, United States: Humana Press. doi:10.1007/978-1-60327-569-9_4


Author Alvarez, Mar
Carrascosa, Laura G.
Zinoviev, Kiril
Plaza, J.ose A.
Lechuga, Laura M.
Title of chapter Biosensors based on cantilevers
Title of book Biosensors and biodetection : methods and protocols
Place of Publication New York , NY, United States
Publisher Humana Press
Publication Year 2009
Sub-type Chapter in textbook
DOI 10.1007/978-1-60327-569-9_4
Year available 2009
Series Methods in molecular biology
ISBN 9781603275668
1603275665
9781603275675
1603275673
9781603275682
Editor Rasooly, Avraham
Herold, Keith E.
Volume number 503-504
Chapter number 4
Start page 51
End page 71
Total pages 21
Total chapters 24
Collection year 2010
Language eng
Formatted Abstract/Summary
Microcantilevers based-biosensors are a new label-free technique that allows the direct detection of biomolecular interactions in a label-less way and with great accuracy by translating the biointeraction into a nanomechanical motion. Low cost and reliable standard silicon technologies are widely used for the fabrication
of cantilevers with well-controlled mechanical properties. Over the last years, the number of applications of these sensors has shown a fast growth in diverse fields, such as genomic or proteomic, because of the biosensor flexibility, the low sample consumption, and the non-pretreated samples required. In this chapter, we report a dedicated design and a fabrication process of highly sensitive microcantilever
silicon sensors. We will describe as well an application of the device in the environmental field showing the immunodetection of an organic toxic pesticide as an example. The cantilever biofunctionalization process and the subsequent pesticide determination are detected in real time by monitoring the nanometer-scale
bending of the microcantilever due to a differential surface stress generated between both surfaces of the device.
Keyword Microcantilever
Nanomechanical biosensors
Immunoassay
Pesticide detection
Surface Stress
Biofunctionalization
Q-Index Code BX
Q-Index Status Provisional Code
Institutional Status Non-UQ

 
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Created: Thu, 11 Apr 2013, 16:31:40 EST by Laura Garcia Carrascosa on behalf of Aust Institute for Bioengineering & Nanotechnology