Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats

Spanevello, Mark Damien, Tajouri, Sophie Ines, Mirciov, Cornel, Kurniawan, Nyoman, Pearse, Martin John, Fabri, Louis Jerry, Owczarek, Catherine Mary, Hardy, Matthew Philip, Bradford, Rebecca Anne, Ramunno, Melanie Louise, Turnley, Ann Maree, Ruitenberg, Marc Jan, Boyd, Andrew Wallace and Bartlett, Perry Francis (2013) Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats. Journal of Neurotrauma, 30 12: 1023-1034. doi:10.1089/neu.2012.2729

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Author Spanevello, Mark Damien
Tajouri, Sophie Ines
Mirciov, Cornel
Kurniawan, Nyoman
Pearse, Martin John
Fabri, Louis Jerry
Owczarek, Catherine Mary
Hardy, Matthew Philip
Bradford, Rebecca Anne
Ramunno, Melanie Louise
Turnley, Ann Maree
Ruitenberg, Marc Jan
Boyd, Andrew Wallace
Bartlett, Perry Francis
Title Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats
Journal name Journal of Neurotrauma   Check publisher's open access policy
ISSN 0897-7151
1557-9042
Publication date 2013-04-04
Sub-type Article (original research)
DOI 10.1089/neu.2012.2729
Open Access Status File (Author Post-print)
Volume 30
Issue 12
Start page 1023
End page 1034
Total pages 12
Place of publication New Rochelle, NY, United States
Publisher Mary Ann Liebert
Collection year 2014
Language eng
Abstract Blocking the action of inhibitory molecules at sites of central nervous system injury has been proposed as a strategy to promote axonal regeneration and functional recovery. We have previously shown that genetic deletion or competitive antagonism of EphA4 receptor activity promotes axonal regeneration and functional recovery in a mouse model of lateral hemisection spinal cord injury. Here we have assessed the effect of blocking EphA4 activation using the competitive antagonist EphA4-Fc in a rat model of thoracic contusive spinal cord injury. Using a ledged tapered balance beam and open-field testing, we observed significant improvements in recovery of locomotor function after EphA4-Fc treatment. Consistent with functional improvement, using high-resolution ex vivo magnetic resonance imaging at 16.4T, we found that rats treated with EphA4-Fc had a significantly increased cross-sectional area of the dorsal funiculus caudal to the injury epicenter compared with controls. Our findings indicate that EphA4-Fc promotes functional recovery following contusive spinal cord injury and provides further support for the therapeutic benefit of treatment with the competitive antagonist in acute cases of spinal cord injury.
Keyword EphA4
Magnetic resonance imaging
Neurotrauma
Spinal cord injury
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Thu, 11 Apr 2013, 08:42:57 EST by Marc Ruitenberg on behalf of Queensland Brain Institute