Epigenetic inheritance and reprogramming in plants and fission yeast

Martienssen, R. A., Kloc, A., Slotkin, R. K. and Tanurdzic, M. (2008). Epigenetic inheritance and reprogramming in plants and fission yeast. In: Control and Regulation of Stem Cells. 73rd Cold Spring Harbor Symposium on Quantitative Biology, Cold Spring Harbor, NY, New York, (265-271). 28 May - 2 June 2008. doi:10.1101/sqb.2008.73.062


Author Martienssen, R. A.
Kloc, A.
Slotkin, R. K.
Tanurdzic, M.
Title of paper Epigenetic inheritance and reprogramming in plants and fission yeast
Conference name 73rd Cold Spring Harbor Symposium on Quantitative Biology
Conference location Cold Spring Harbor, NY, New York
Conference dates 28 May - 2 June 2008
Proceedings title Control and Regulation of Stem Cells   Check publisher's open access policy
Journal name Cold Spring Harbor Symposia on Quantitative Biology   Check publisher's open access policy
Place of Publication Woodbury, NY, United States
Publisher Cold Spring Harbor Laboratory Press
Publication Year 2008
Sub-type Fully published paper
DOI 10.1101/sqb.2008.73.062
ISBN 9780879698621
ISSN 0091-7451
1943-4456
Volume 73
Start page 265
End page 271
Total pages 7
Language eng
Abstract/Summary Plants and fission yeast exhibit a wealth of epigenetic phenomena, including transposon regulation, heterochromatic silencing, and gene imprinting. They provide excellent model organisms to address the question of how epigenetic information is propagated to daughter cells. We have addressed the questions of establishment, maintenance, and inheritance of heterochromatic silencing using the fission yeast Schizosaccharomyces pombe and the plant Arabidopsis thaliana by using a variety of genetic and genomic approaches. We present here results showing the cell cycle dependence of RNA in fission yeast RNA interference (RNAi), which is required for proper transcriptional silencing of the centromeric heterochromatin, and that this process occurs during S phase, allowing for precise copying and reestablishment of heterochromatic histone modifications following DNA replication and cell division. We also show that in plants, cells in culture and male germ-line cells undergo massive epigenomic changes correlated with the appearance of a novel class of 21-nucleotide small interfering RNA (siRNA) from transcriptionally reactivated transposable elements (TEs) following loss of heterochromatic DNA and histone methylation. We propose a model for the role of deliberate TE reactivation in germ-line companion cells as part of a developmental mechanism for first revealing and then silencing TEs via small RNA, which may contribute to reprogramming during early development in plants and animals.
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: School of Biological Sciences Publications
 
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Created: Mon, 08 Apr 2013, 22:05:41 EST by Gail Walter on behalf of School of Biological Sciences