Perineural invasion of head and neck skin cancer: diagnostic and therapeutic implications

Panizza, Benedict and Warren, Timothy (2013) Perineural invasion of head and neck skin cancer: diagnostic and therapeutic implications. Current Oncology Reports, 15 2: 128-133. doi:10.1007/s11912-012-0288-y

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Author Panizza, Benedict
Warren, Timothy
Title Perineural invasion of head and neck skin cancer: diagnostic and therapeutic implications
Journal name Current Oncology Reports   Check publisher's open access policy
ISSN 1523-3790
1534-6269
Publication date 2013-04
Year available 2012
Sub-type Article (original research)
DOI 10.1007/s11912-012-0288-y
Volume 15
Issue 2
Start page 128
End page 133
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Current Science
Collection year 2013
Language eng
Abstract Perineural invasion of head and neck skin cancer is a poorly understood and often misdiagnosed pathological entity. Incidental or microscopic perineural invasion is identified by the pathologist and often leads to confusion as to how the patient should be further treated. The less common but more aggressive clinical perineural spread presents with a clinical deficit, which is too commonly misinterpreted by the clinician. This review will try to clarify the terminology that exists in the literature and explore the mechanisms of invasion and spread. It will look at the recent advances in diagnosis and comment on the limitations inherent in current classification schemes. A review of outcomes will be included and current treatment strategies utilized discussed.
Keyword Perineural invasion
Neurotropism
Skin cancer
Squamous cell carcinoma
Skull base surgery
Staging
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 27 December 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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