Structure and function of long noncoding RNAs in epigenetic regulation

Mercer, Tim R. and Mattick, John S. (2013) Structure and function of long noncoding RNAs in epigenetic regulation. Nature Structural & Molecular Biology, 20 3: 300-307. doi:10.1038/nsmb.2480


Author Mercer, Tim R.
Mattick, John S.
Title Structure and function of long noncoding RNAs in epigenetic regulation
Journal name Nature Structural & Molecular Biology   Check publisher's open access policy
ISSN 1545-9993
1545-9985
Publication date 2013-03
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nsmb.2480
Volume 20
Issue 3
Start page 300
End page 307
Total pages 8
Place of publication New York, NY, United States
Publisher Nature Publishing
Collection year 2014
Language eng
Abstract Genomes of complex organisms encode an abundance and diversity of long noncoding RNAs (lncRNAs) that are expressed throughout the cell and fulfill a wide variety of regulatory roles at almost every stage of gene expression. These roles, which encompass sensory, guiding, scaffolding and allosteric capacities, derive from folded modular domains in lncRNAs. In this diverse functional repertoire, we focus on the well-characterized ability for lncRNAs to function as epigenetic modulators. Many lncRNAs bind to chromatin-modifying proteins and recruit their catalytic activity to specific sites in the genome, thereby modulating chromatin states and impacting gene expression. Considering this regulatory potential in combination with the abundance of lncRNAs suggests that lncRNAs may be part of a broad epigenetic regulatory network.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 315 times in Thomson Reuters Web of Science Article | Citations
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