Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model

Farrell, Helen E., Abraham, Alexander M., Cardin, Rhonda D., Molleskov-Jensen, Ann-Sofie, Rosenkilde, Mette M. and Davis-Poynter, Nicholas (2013) Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model. Journal of Virology, 87 7: 4112-4117. doi:10.1128/JVI.03406-12


Author Farrell, Helen E.
Abraham, Alexander M.
Cardin, Rhonda D.
Molleskov-Jensen, Ann-Sofie
Rosenkilde, Mette M.
Davis-Poynter, Nicholas
Title Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model
Formatted title
 Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 2013-04
Sub-type Article (original research)
DOI 10.1128/JVI.03406-12
Open Access Status DOI
Volume 87
Issue 7
Start page 4112
End page 4117
Total pages 6
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2014
Language eng
Abstract The mouse cytomegalovirus chemokine receptor homologue (CKR) M33 is required for salivary gland tropism and efficient reactivation from latency, phenotypes partially rescued by the human cytomegalovirus CKR US28. Herein, we demonstrate that complementation of salivary gland tropism is mediated predominantly by G protein-dependent signaling conserved with that of M33; in contrast, both G protein-dependent and -independent pathways contribute to the latency phenotypes. A novel M33-dependent replication phenotype in cultured bone marrow macrophages is also described.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Clinical Medical Virology Centre Publications
 
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