Overlapped metabolic and therapeutic links between Alzheimer and diabetes

Ahmad, Waqar (2013) Overlapped metabolic and therapeutic links between Alzheimer and diabetes. Molecular Neurobiology, 47 1: 399-424. doi:10.1007/s12035-012-8352-z


Author Ahmad, Waqar
Title Overlapped metabolic and therapeutic links between Alzheimer and diabetes
Journal name Molecular Neurobiology   Check publisher's open access policy
ISSN 0893-7648
1559-1182
Publication date 2013-02
Year available 2012
Sub-type Article (original research)
DOI 10.1007/s12035-012-8352-z
Volume 47
Issue 1
Start page 399
End page 424
Total pages 26
Place of publication Totowa, NJ, United States
Publisher Humana Press
Collection year 2014
Language eng
Formatted abstract
Alzheimer’s disease (AD) and diabetes are among the most common diseases associated with ageing. The pathology of AD is strongly associated with accumulated misfolding proteins that results in neuronal dysfunction within the brain. Diabetes, on the contrary, is characterised by altered insulin signaling that results in reduced glucose uptake, metabolic suppression of energy consuming cells and conversion of glucose to fat in the liver. Despite distinguishing features, these diseases share common elements and may in fact be viewed as fundamentally similar disorders that differ in magnitude of specific traits, primarily affected tissues and time of onset. In this review, we outline the fundamental basis of each of the two diseases and highlight similarities in their pathophysiology. Further ahead we will discuss these features in relation to the development of drugs to treat these two diseases, particularly AD, for which the development of therapeutic chemicals has  proven to be particularly difficult. We conclude with comments on efforts to develop a simple organism, Caenorhabditis elegans, as a genetic model to be used to study the systems biology of diabetes and AD.
Keyword Alzheimer's disease
Diabetes
Pathophysiology
Impaired metabolism
Therapies
C. elegans
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 26 September 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biological Sciences Publications
 
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