M-protein-derived conformational peptide epitope vaccine candidate against Group A Streptococcus

Skwarczynski, Mariusz, Kamaruzaman, Khairul A., Srinivasan, Saranya, Zaman, Mehfuz, Lin, I-Chun, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2013) M-protein-derived conformational peptide epitope vaccine candidate against Group A Streptococcus. Current Drug Delivery, 10 1: 39-45. doi:10.2174/1567201811310010007

Author Skwarczynski, Mariusz
Kamaruzaman, Khairul A.
Srinivasan, Saranya
Zaman, Mehfuz
Lin, I-Chun
Batzloff, Michael R.
Good, Michael F.
Toth, Istvan
Title M-protein-derived conformational peptide epitope vaccine candidate against Group A Streptococcus
Journal name Current Drug Delivery   Check publisher's open access policy
ISSN 1567-2018
Publication date 2013-02
Year available 2013
Sub-type Article (original research)
DOI 10.2174/1567201811310010007
Volume 10
Issue 1
Start page 39
End page 45
Total pages 7
Place of publication Netherlands
Publisher Bentham Science Publishers
Collection year 2014
Language eng
Formatted abstract
Identification of the most relevant epitopes is the initial challenge of peptide-based vaccine design. Chimeric conserved epitopes of the Group A Streptococcus (GAS) M-protein were used in the development of an anti-GAS vaccine candidate. Previously, these epitopes have incorporated a GCN4 peptide from yeast to maintain their native helical structure. Here, we designed a new peptide epitope based on the minimal B-cell epitope from GAS M-protein. This new epitope was able to adopt the desired helical conformation without the need for the foreign GCN4 flanking sequence. The selected epitope induced significant immune responses upon administration with external adjuvant, and when incorporated into the Lipid Core Peptide (LCP) system. Moreover, the antibodies produced against this epitope were able to recognize the native p145 sequence from M-protein.
Keyword Lipid core peptide
Group A streptococcus
B-cell epitope
Conformational epitope
Peptide vaccine
B-cell epitopes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Fri, 05 Apr 2013, 10:20:05 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences