Histone deacetylase inhibitors disrupt the mitotic spindle assembly checkpoint by targeting histone and nonhistone proteins

Gabrielli, Brian and Brown, Melissa (2012) Histone deacetylase inhibitors disrupt the mitotic spindle assembly checkpoint by targeting histone and nonhistone proteins. Advances in Cancer Research, 116 1-37. doi:10.1016/B978-0-12-394387-3.00001-X

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Author Gabrielli, Brian
Brown, Melissa
Title Histone deacetylase inhibitors disrupt the mitotic spindle assembly checkpoint by targeting histone and nonhistone proteins
Journal name Advances in Cancer Research   Check publisher's open access policy
ISSN 0065-230X
2162-5557
ISBN 9780123943873
Publication date 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/B978-0-12-394387-3.00001-X
Volume 116
Start page 1
End page 37
Total pages 37
Editor Steven Grant
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2013
Language eng
Formatted abstract
Histone deacetylase inhibitors exhibit pleiotropic effects on cell functions, both in vivo and in vitro. One of the more dramatic effects of these drugs is their ability to disrupt normal mitotic division, which is a significant contributor to the anticancer properties of these drugs. The most important feature of the disrupted mitosis is that drug treatment overcomes the mitotic spindle assembly checkpoint and drives mitotic slippage, but in a manner that triggers apoptosis. The mechanism by which histone deacetylase inhibitors affect mitosis is now becoming clearer through the identification of a number of chromatin and nonchromatin protein targets that are critical to the regulation of normal mitotic progression and cell division. These proteins are directly regulated by acetylation and deacetylation, or in some cases indirectly through the acetylation of essential partner proteins. There appears to be little contribution from deacetylase inhibitor-induced transcriptional changes to the mitotic effects of these drugs. The overall mitotic phenotype of drug treatment appears to be the sum of these disrupted mechanisms.
Keyword Spindle assembly checkpoint
Aurora B
Survivin
Chromosomal passenger complex
Plk1
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Wed, 27 Mar 2013, 13:20:42 EST by Brian Gabrielli on behalf of School of Biomedical Sciences