The role of n-3 polyunsaturated fatty acids in human heart failure

Poudyal, Hemant and Brown, Lindsay (2013) The role of n-3 polyunsaturated fatty acids in human heart failure. Endocrine, Metabolic & Immune Disorders - Drug Targets, 13 1: 105-117. doi:10.2174/1871530311313010013

Author Poudyal, Hemant
Brown, Lindsay
Title The role of n-3 polyunsaturated fatty acids in human heart failure
Journal name Endocrine, Metabolic & Immune Disorders - Drug Targets   Check publisher's open access policy
ISSN 1871-5303
Publication date 2013
Sub-type Article (original research)
DOI 10.2174/1871530311313010013
Volume 13
Issue 1
Start page 105
End page 117
Total pages 13
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2014
Language eng
Abstract n-3 polyunsaturated fatty acids (PUFA) have been proposed as potential treatments for human heart failure. The cardioprotective effects of n-3 PUFA are supported by extensive cell culture, animal and human studies. Animal studies with n-3 PUFA have shown marked improvements in many independent risk factors for heart failure, including obesity, type II diabetes, insulin resistance, hypertension and inflammation. However, the evidence from observational studies, randomised controlled trials and meta-analyses that these benefits on risk factors lead to improvements in the symptoms of heart failure in patients is much less convincing. Further, most studies have used marine n-3 PUFA; the role of the plant-derived PUFA, α-linolenic acid (ALA), is even less clear. This discontinuity of scientific evidence from animal to human studies suggests that future studies should focus on defining the optimal dosage range and the efficacy of n-3 PUFA compared to standard treatments using standardised study designs. Further studies on ALA would seem justified.
Keyword Alpha-linolenic acid
Docosahexaenoic acid
Eicosapentaenoic acid
Heart failure
Omega-3 fatty acids
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
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Created: Tue, 26 Mar 2013, 10:51:15 EST by Ms Joanne Biles on behalf of School of Biomedical Sciences