Potential predictive biomarkers of obesity in Burmese cats

Lee, Peter, Mori, Akihiro, Coradini, Marcia, Mori, Nobuko, Sagara, Fumi, Yamamoto, Ichiro, Rand, Jacquie S. and Arai, Toshiro (2013) Potential predictive biomarkers of obesity in Burmese cats. Veterinary Journal, 195 2: 221-227. doi:10.1016/j.tvjl.2012.06.027


Author Lee, Peter
Mori, Akihiro
Coradini, Marcia
Mori, Nobuko
Sagara, Fumi
Yamamoto, Ichiro
Rand, Jacquie S.
Arai, Toshiro
Title Potential predictive biomarkers of obesity in Burmese cats
Journal name Veterinary Journal   Check publisher's open access policy
ISSN 1090-0233
1532-2971
Publication date 2013-02-01
Sub-type Article (original research)
DOI 10.1016/j.tvjl.2012.06.027
Volume 195
Issue 2
Start page 221
End page 227
Total pages 7
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Australian Burmese cats are predisposed to diabetes mellitus and, compared to other breeds, have delayed triglyceride clearance that may result in subtle changes within cells and tissues that trigger specific alterations in gene expression within peripheral blood leucocytes (PBLs). Expression of genes involved in energy metabolism (glucose-6-phosphate dehydrogenase and malate dehydrogenase), lipogenesis (ATP citrate lyase [ACL], fatty acid synthase [FAS] and sterol regulatory binding protein-1c [SREBP-1c]), and insulin signalling (insulin receptor substrates 1 and 2, and phosphatidylinositol-3 kinase), as well as cholesterol lipoprotein subfraction profiling were carried out on PBLs from lean Burmese cats and compared with similar profiles of age and gender matched lean and obese Australian domestic shorthaired cats (DSHs) in an attempt to identify possible biomarkers for assessing obesity.

For the majority of the genes examined, the lean Burmese cats demonstrated similar PBL gene expression patterns as age and gender matched obese Australian DSH cats. Lean Burmese had increased expression of ACL and FAS, but not SREBP-1c, a main upstream regulator of lipid synthesis, suggesting possible aberrations in lipogenesis. Moreover, lean Burmese displayed a 3- to 4-fold increase in the very low density cholesterol fraction percentage, which was double that for obese DSH cats, indicating an increased degree of lipid dysregulation especially in relation to triglycerides. The findings suggest that Burmese cats may have a particular propensity for dysregulation in lipid metabolism.
Keyword Cat
Burmese
mRNA
Biomarker
Obesity
Peripheral blood leucocyte
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Veterinary Science Publications
 
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