Cognitive impairment has a strong relation to nonsomatic symptoms of depression in relapsing-remitting multiple sclerosis

Sundgren, Mathias, Maurex, Liselotte, Wahlin, Ake, Piehl, Fredrik and Brismar, Tom (2013) Cognitive impairment has a strong relation to nonsomatic symptoms of depression in relapsing-remitting multiple sclerosis. Archives of Clinical Neuropsychology, 28 2: 144-155. doi:10.1093/arclin/acs113


Author Sundgren, Mathias
Maurex, Liselotte
Wahlin, Ake
Piehl, Fredrik
Brismar, Tom
Title Cognitive impairment has a strong relation to nonsomatic symptoms of depression in relapsing-remitting multiple sclerosis
Journal name Archives of Clinical Neuropsychology   Check publisher's open access policy
ISSN 0887-6177
1873-5843
Publication date 2013-03
Sub-type Article (original research)
DOI 10.1093/arclin/acs113
Volume 28
Issue 2
Start page 144
End page 155
Total pages 12
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2014
Language eng
Abstract It is unclear how cognitive impairment in multiple sclerosis (MS) is influenced by physical disability, fatigue, and depression. Our aim was to identify the strongest clinical predictors for cognitive impairment in relapsing-remitting MS (RRMS) patients. The clinical risk factors included in the analysis were physical disability (EDSS), fatigue (FSS), the somatic and nonsomatic components of depression (BDI), disease progression rate [Multiple Sclerosis Severity Score (MSSS)], and psychotropic medication. Cognitive impairment had a prevalence of 30.5% in patients affecting preferentially attention, executive functions, processing speed and visual perception/organization. MSSS was not associated with cognitive impairment, depression, or fatigue. In regression models, cognitive performance was best predicted by the nonsomatic symptoms of depression alone or in combination with physical disability. Exclusion of patients with any psychotropic medication did not influence the results. Our results underscore the importance of evaluating depressive symptoms when suspecting cognitive impairment in patients with RRMS.
Keyword Multiple sclerosis
Neuropsychological assessment
Depression
Physical disability
Fatigue
Psychotropic medication
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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