Venom peptides as a rich source of Cav2.2 channel blockers

Sousa, Silmara R., Vetter, Irina and Lewis, Richard J. (2013) Venom peptides as a rich source of Cav2.2 channel blockers. Toxins, 5 2: 286-314. doi:10.3390/toxins5020286

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Sousa, Silmara R.
Vetter, Irina
Lewis, Richard J.
Title Venom peptides as a rich source of Cav2.2 channel blockers
Journal name Toxins   Check publisher's open access policy
ISSN 2072-6651
Publication date 2013-02-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/toxins5020286
Open Access Status DOI
Volume 5
Issue 2
Start page 286
End page 314
Total pages 29
Place of publication Basel, Switzerland
Publisher M D P I AG
Collection year 2014
Language eng
Abstract Cav2.2 is a calcium channel subtype localized at nerve terminals, including nociceptive fibers, where it initiates neurotransmitter release. Cav2.2 is an important contributor to synaptic transmission in ascending pain pathways, and is up-regulated in the spinal cord in chronic pain states along with the auxiliary α2δ1 subunit. It is therefore not surprising that toxins that inhibit Cav2.2 are analgesic. Venomous animals, such as cone snails, spiders, snakes, assassin bugs, centipedes and scorpions are rich sources of remarkably potent and selective Cav2.2 inhibitors. However, side effects in humans currently limit their clinical use. Here we review Cav2.2 inhibitors from venoms and their potential as drug leads.
Keyword Ca(v)2.2
Voltage-gated calcium channels
Nociception
Neurotransmitter
Omega-conotoxins
ω-conotoxins
Venom peptides
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 24 Mar 2013, 10:18:58 EST by System User on behalf of Institute for Molecular Bioscience