Endometrial cancer: diagnosis, treatment and prevention

Fung, Jenny N.T. and Chen, Chen (2012). Endometrial cancer: diagnosis, treatment and prevention. In Hiroto S. Watanabe (Ed.), Horizons in cancer research. Volume 49 (pp. 1-32) Hauppauge, NY, USA: Nova Publishers.

Author Fung, Jenny N.T.
Chen, Chen
Title of chapter Endometrial cancer: diagnosis, treatment and prevention
Title of book Horizons in cancer research. Volume 49
Place of Publication Hauppauge, NY, USA
Publisher Nova Publishers
Publication Year 2012
Sub-type Chapter in textbook
Series Horizons in Cancer Research
ISBN 9781619424067
Editor Hiroto S. Watanabe
Volume number 49
Chapter number 1
Start page 1
End page 32
Total pages 32
Total chapters 9
Collection year 2013
Language eng
Abstract/Summary Endometrial cancer is the most common gynecological cancer in many developed countries and incidence is increasing along the life style changes. It is a polygenic and multi-factorial disease, for which estrogen has been recognized as the main risk factor. Most cases are diagnosed in early, more favorable stages, where surgery is the main treatment strategy. There are other treatment options, which include radiotherapy, chemotherapy and hormone treatment with oral or local progesterone, to reduce the risk of loco-regional and distant disease recurrence. The resistance to these treatments and advanced stage of the disease are the great therapeutic challenges. Despite endometrial cancer being a major contributor to cancer morbidity and mortality, diagnosis and treatment of this disease has remained relatively unchanged over the last few decades. Knowledge of endometrial cancer risks, taken together with the risks and benefits of the intervention, is essential to choose an appropriate disease management strategy. This chapter reviews the current knowledge and recent developments in the management of endometrial cancer. We discuss newly discovered genetic variants, molecular biomarkers, inflammatory markers and hormone therapies, as well as the related regulatory factors and signaling pathways that potentially control the growth of endometrial tumors. The integration of these factors into conventional diagnostic and therapeutic strategies could potentially lead to more specific treatments for individual patients. Furthermore by identifying the new risk factors and the benefit of any lifestyle intervention approaches, it offers the ability to educate those at very high risk about cancer prevention, early detection of endometrial cancer, and improvement of clinic outcomes.
Q-Index Code BX
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Tue, 19 Mar 2013, 09:47:35 EST by Ms Joanne Biles on behalf of School of Biomedical Sciences