The plasmacytoid dendritic cell: a cell at the cross-roads in asthma

Lynch, Jason P., Mazzone, Stuart B., Rogers, Matthew J., Arikkatt, Jaisy J., Loh, Zhixuan, Pritchard, Antonia L., Upham, John W. and Phipps, Simon (2014) The plasmacytoid dendritic cell: a cell at the cross-roads in asthma. European Respiratory Journal, 43 1: 264-275. doi:10.1183/09031936.00203412

Author Lynch, Jason P.
Mazzone, Stuart B.
Rogers, Matthew J.
Arikkatt, Jaisy J.
Loh, Zhixuan
Pritchard, Antonia L.
Upham, John W.
Phipps, Simon
Title The plasmacytoid dendritic cell: a cell at the cross-roads in asthma
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
Publication date 2014-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1183/09031936.00203412
Open Access Status
Volume 43
Issue 1
Start page 264
End page 275
Total pages 32
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Collection year 2014
Language eng
Abstract The onset, progression and exacerbations of asthma are frequently associated with virus infections of the lower respiratory tract. An emerging paradigm suggests that this relationship may be underpinned by a defect in the host’s antiviral response, typified by the impaired production of type I and type III IFNs. The failure to control viral burden likely causes damage to the lung architecture and contributes to an aberrant immune response, which together, compromise lung function. Although a relatively rare cell type, the plasmacytoid dendritic cell dedicates much of its transcriptome to the synthesis of IFNs and is pre-armed with virus-sensing pattern recognition receptors. Thus, pDCs are specialised to ensure early viral detection and the rapid induction of the antiviral state to block viral replication and spread. In addition, pDC can also limit immunopathology, and promote peripheral tolerance to prevent allergic sensitisation to harmless antigens, possibly through the induction of regulatory T cells. Thus, this enigmatic cell may lie at an important intersection; orchestrating the immediate phase of antiviral immunity to effect viral clearance while regulating tolerance. Here we review the evidence to support the hypothesis that a primary defect in pDC function may underlie the development of asthma.
Keyword Asthma
Th2 responses
Toll-like receptor 7
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online before print: 21 February 2013.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
School of Medicine Publications
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Created: Mon, 18 Mar 2013, 17:48:57 EST by Zhixuan Loh on behalf of School of Biomedical Sciences