Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis

Beverdam, Annemiek, Claxton, Christina, Zhang, Xiaomeng, James, Gregory, Harvey, Kieran F. and Key, Brian (2013) Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis. Journal of Investigative Dermatology, 133 6: 1497-1505. doi:10.1038/jid.2012.430


Author Beverdam, Annemiek
Claxton, Christina
Zhang, Xiaomeng
James, Gregory
Harvey, Kieran F.
Key, Brian
Title Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis
Formatted title
Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis
Journal name Journal of Investigative Dermatology   Check publisher's open access policy
ISSN 0022-202X
1523-1747
Publication date 2013-06
Year available 2012
Sub-type Article (original research)
DOI 10.1038/jid.2012.430
Volume 133
Issue 6
Start page 1497
End page 1505
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2013
Language eng
Formatted abstract
Tissue renewal is an ongoing process in the epithelium of the skin. We have begun to examine the genetic mechanisms that control stem/progenitor cell activation in the postnatal epidermis. The conserved Hippo pathway regulates stem cell turnover in arthropods through to vertebrates. Here we show that its downstream effector, yes-associated protein (YAP), is active in the stem/progenitor cells of the postnatal epidermis.  Overexpression of a C-terminally truncated YAP mutant in the basal epidermis of transgenic mice caused marked expansion of epidermal stem/progenitor cell populations. Our data suggest that the C-terminus of YAP controls the balance between stem/progenitor cell proliferation and differentiation in the postnatal interfollicular epidermis. We conclude that YAP functions as a molecular switch of stem/progenitor cell activation in the epidermis. Moreover, our results highlight YAP as a possible therapeutic target for diseases such as skin cancer, psoriasis, and epidermolysis bullosa.
Keyword Cell proliferation
Tissue renewal
Postnatal
Yes-associated protein
Hair follicle morphogenesis
Ovarian-cancer oncogene
Epithelial stem-cells
Organ size control
Hippo pathway
beta-Catenin
β-Catenin
Transcriptional coactivator
Hepatocellular-carcinoma
Transient activation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 29 November 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
 
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Created: Mon, 18 Mar 2013, 16:12:19 EST by Professor Brian Key on behalf of School of Biomedical Sciences