Efficient chemical synthesis of human complement protein C3a

Ghassemian, Artin, Wang, Ching-I Anderson, Yau, Mei-Kwan, Reid, Robert C., Lewis, Richard J., Fairlie, David P., Alewood, Paul F. and Durek, Thomas (2013) Efficient chemical synthesis of human complement protein C3a. Chemical Communications, 49 23: 2356-2358. doi:10.1039/c3cc40537k

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Author Ghassemian, Artin
Wang, Ching-I Anderson
Yau, Mei-Kwan
Reid, Robert C.
Lewis, Richard J.
Fairlie, David P.
Alewood, Paul F.
Durek, Thomas
Title Efficient chemical synthesis of human complement protein C3a
Journal name Chemical Communications   Check publisher's open access policy
ISSN 1359-7345
Publication date 2013-01
Sub-type Article (original research)
DOI 10.1039/c3cc40537k
Open Access Status File (Author Post-print)
Volume 49
Issue 23
Start page 2356
End page 2358
Total pages 3
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Collection year 2014
Language eng
Abstract We report the total chemical synthesis of human C3a by one-pot native chemical ligation of three unprotected peptide segments, followed by efficient in vitro folding that yielded the anaphylatoxin C3a in high yield and excellent purity. Synthetic C3a was fully active and its crystal structure at 2.1 Å resolution showed 3 helices and a C-terminal turn motif.
Keyword C3a
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
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Created: Sun, 17 Mar 2013, 01:19:23 EST by System User on behalf of Examinations