The risk of Barrett's esophagus associated with abdominal obesity in males and females

Kendall, Bradley J., Macdonald, Graeme A., Hayward, Nicholas K., Prins, Johannes B., O'Brien, Suzanne, Whiteman, David C., Study of Digestive Health, Green. Adele C., Parsons, Peter G., Pavey, Sandra J., Purdie, David M. and Webb, Penelope M. (2013) The risk of Barrett's esophagus associated with abdominal obesity in males and females. International Journal of Cancer, 132 9: 2192-2199. doi:10.1002/ijc.27887

Author Kendall, Bradley J.
Macdonald, Graeme A.
Hayward, Nicholas K.
Prins, Johannes B.
O'Brien, Suzanne
Whiteman, David C.
Study of Digestive Health
Green. Adele C.
Parsons, Peter G.
Pavey, Sandra J.
Purdie, David M.
Webb, Penelope M.
Total Author Count Override 6
Title The risk of Barrett's esophagus associated with abdominal obesity in males and females
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 0020-7136
Publication date 2013-05-01
Year available 2012
Sub-type Article (original research)
DOI 10.1002/ijc.27887
Open Access Status
Volume 132
Issue 9
Start page 2192
End page 2199
Total pages 8
Place of publication Hoboken, United States
Publisher John Wiley & Sons
Collection year 2013
Language eng
Abstract Esophageal adenocarcinoma arises from Barrett's esophagus (BE). Both occur predominantly in males. The role of abdominal obesity in this sex distribution is uncertain. Our study aimed to determine whether there is an association between abdominal obesity and risk of BE and if present was it modified by sex. A structured interview and anthropometric measures were conducted within a population-based case–control study. We recruited 237 BE cases (70% male) and 247 population controls, frequency matched by age and sex. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable logistic regression analysis. In the overall group and males, all measures of abdominal obesity [waist circumference (WC), waist–hip ratio (WHR), sagittal abdominal diameter (SAD) and waist–height ratio (WHtR)] were strongly associated with risk of BE (Overall: WC OR 2.2 95% CI 1.4–3.5, WHR 1.8 95% CI 1.2–2.9, SAD 2.3 95% CI 1.4–3.7, WHtR 1.9 95% CI 1.2–3.0, males WC 2.5 95% CI 1.4–4.3, WHR 2.4 95% CI 1.3–4.2, SAD 2.5 95% CI 1.4–4.3, WHtR 1.9 95% CI 1.1–3.4). These associations were minimally attenuated by adjusting for ever-symptoms of gastroesophageal reflux (GER). These findings suggest in males, non-GER factors related to abdominal obesity may be important in the development of BE. In females, there was modest association between measures of abdominal obesity and risk of BE but these were all abolished after adjusting for ever-symptoms of GER. The power to detect differences between sexes in the risk of BE associated with abdominal obesity was limited by the number of females in the study.
Keyword Barrett's esophagus
Risk factors
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published onine 3 October 2012.

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