Queensland Lung Cancer Screening Study: rationale, design and methods

Marshall, H. M., Bowman, R. V., Crossin, J., Lau, M. A., Slaughter, R. E., Passmore, L. H., McCaul, E. M., Courtney, D. A., Windsor, M. N., Yang, I. A., Smith, I. R., Keir, B. J., Hayes, T. J., Redmond, S. J., Zimmerman, P. V. and Fong, K. M. (2013) Queensland Lung Cancer Screening Study: rationale, design and methods. Internal Medicine Journal, 43 2: 174-182. doi:10.1111/j.1445-5994.2012.02789.x

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Author Marshall, H. M.
Bowman, R. V.
Crossin, J.
Lau, M. A.
Slaughter, R. E.
Passmore, L. H.
McCaul, E. M.
Courtney, D. A.
Windsor, M. N.
Yang, I. A.
Smith, I. R.
Keir, B. J.
Hayes, T. J.
Redmond, S. J.
Zimmerman, P. V.
Fong, K. M.
Title Queensland Lung Cancer Screening Study: rationale, design and methods
Journal name Internal Medicine Journal   Check publisher's open access policy
ISSN 1444-0903
Publication date 2013-02-12
Year available 2013
Sub-type Article (original research)
DOI 10.1111/j.1445-5994.2012.02789.x
Open Access Status
Volume 43
Issue 2
Start page 174
End page 182
Total pages 9
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2014
Language eng
Formatted abstract
Background: Lung cancer is the leading cause of cancer-related mortality in Australia. Screening using low-dose computed tomography (LDCT) can reduce lung cancer mortality. The feasibility of screening in Australia is unknown. This paper describes the rationale, design and methods of the Queensland Lung Cancer Screening Study.
Aims: The aim of the study is to describe the methodology for a feasibility study of lung cancer screening by LDCT in Australia.
Methods: The Queensland Lung Cancer Screening Study is an ongoing, prospective observational study of screening by LDCT at a single tertiary institution. Healthy volunteers at high risk of lung cancer (age 60–74 years; smoking history ≥30 pack years, current or quit within 15 years; forced expiratory volume in 1s≥50% predicted) are recruited from the general public through newspaper advertisement and press release. Participants receive a LDCT scan of the chest at baseline, year 1 and year 2 using a multidetector helical computed tomography scanner and are followed up for a total of 5 years. Feasibility of screening will be assessed by cancer detection rates, lung nodule prevalence, optimal management strategies for lung nodules, economic costs, healthcare utilisation and participant quality of life.
Conclusions: Studying LDCT screening in the Australian setting will help us understand how differences in populations, background diseases and healthcare structures modulate screening effectiveness. This information, together with results from overseas randomised studies, will inform and facilitate local policymaking.
Keyword Lung neoplasms
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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