Development of figurative language skills following central nervous system-directed chemotherapy delivered in early childhood

Dowling, Emma. K, Lewis, Fiona M. and Murdoch, Bruce E. (2014) Development of figurative language skills following central nervous system-directed chemotherapy delivered in early childhood. International Journal of Speech-Language Pathology, 16 2: 142-150. doi:10.3109/17549507.2013.784806

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Author Dowling, Emma. K
Lewis, Fiona M.
Murdoch, Bruce E.
Title Development of figurative language skills following central nervous system-directed chemotherapy delivered in early childhood
Journal name International Journal of Speech-Language Pathology   Check publisher's open access policy
ISSN 1754-9507
1754-9515
Publication date 2014-04
Year available 2013
Sub-type Article (original research)
DOI 10.3109/17549507.2013.784806
Open Access Status
Volume 16
Issue 2
Start page 142
End page 150
Total pages 9
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2014
Language eng
Abstract Central nervous system (CNS)-directed chemotherapy is delivered for the treatment of childhood acute lymphoblastic leukaemia (ALL). Figurative language deficits have been described in children following CNS-directed chemotherapy; however, comprehensive analysis of figurative interpretation errors, potentially providing clinical utility to assist with intervention planning, has never been performed. The present study aimed to compare the figurative language skills of seven children treated with CNS-directed chemotherapy for ALL before the age of 6 years (mean age at diagnosis 3 years 10 months) and a matched control group of children, using the Test of Language Competence-Expanded Edition (TLC-E) Figurative Language sub-test. It was hypothesised that the children treated with CNS-directed chemotherapy would demonstrate a decreased performance in and an alternative method of interpreting figurative language. The results suggest no negative effects of CNS-directed chemotherapy on figurative language. There were no statistically significant differences between groups for TLC-E Figurative Language sub-test composite scores and picture component errors, nor were there clinically significant differences observed from descriptive comparisons of individual case data and error analysis. As these skills continue to emerge beyond childhood, the need to monitor skill development in ALL survivors beyond childhood is highlighted.
Keyword Central nervous system chemotherapy
Intrathecal chemotherapy
Childhood acute lymphoblastic leukaemia
High-level language skills
Figurative language
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Health and Rehabilitation Sciences Publications
 
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Created: Mon, 11 Mar 2013, 08:20:37 EST by Dr Fiona Lewis on behalf of School of Health & Rehabilitation Sciences