Threshold capabilities: threshold concepts and knowledge capability linked through variation theory

Baillie, Caroline, Bowden, John A. and Meyer, Jan H. F. (2013) Threshold capabilities: threshold concepts and knowledge capability linked through variation theory. Higher Education, 65 2: 227-246. doi:10.1007/s10734-012-9540-5


Author Baillie, Caroline
Bowden, John A.
Meyer, Jan H. F.
Title Threshold capabilities: threshold concepts and knowledge capability linked through variation theory
Journal name Higher Education   Check publisher's open access policy
ISSN 0018-1560
1573-174X
Publication date 2013-02
Year available 2012
Sub-type Article (original research)
DOI 10.1007/s10734-012-9540-5
Open Access Status
Volume 65
Issue 2
Start page 227
End page 246
Total pages 20
Place of publication Dordrecht, Netherlands
Publisher Springer
Collection year 2013
Language eng
Abstract Mouse sex determination provides an attractive model to study how regulatory genetic networks and signaling pathways control cell specification and cell fate decisions. This study characterizes in detail the essential role played by the insulin receptor (INSR) and the IGF type I receptor (IGF1R) in adrenogenital development and primary sex determination. Constitutive ablation of insulin/IGF signaling pathway led to reduced proliferation rate of somatic progenitor cells in both XX and XY gonads prior to sex determination together with the downregulation of hundreds of genes associated with the adrenal, testicular, and ovarian genetic programs. These findings indicate that prior to sex determination somatic progenitors in Insr;Igf1r mutant gonads are not lineage primed and thus incapable of upregulating/repressing the male and female genetic programs required for cell fate restriction. In consequence, embryos lacking functional insulin/IGF signaling exhibit (i) complete agenesis of the adrenal cortex, (ii) embryonic XY gonadal sex reversal, with a delay of Sry upregulation and the subsequent failure of the testicular genetic program, and (iii) a delay in ovarian differentiation so that Insr;Igf1r mutant gonads, irrespective of genetic sex, remained in an extended undifferentiated state, before the ovarian differentiation program ultimately is initiated at around E16.5.
Keyword Threshold concept
Knowledge capability
Unknown future
Variation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 5 June 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Engineering, Architecture and Information Technology Publications
Official 2013 Collection
 
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