Ripples in the pond - using a systems approach to decipher the cellular functions of membrane microdomains

Inder, Kerry L., Davis, Melissa and Hill, Michelle M. (2013) Ripples in the pond - using a systems approach to decipher the cellular functions of membrane microdomains. Molecular Biosystems, 9 3: 330-338. doi:10.1039/c2mb25300c


Author Inder, Kerry L.
Davis, Melissa
Hill, Michelle M.
Title Ripples in the pond - using a systems approach to decipher the cellular functions of membrane microdomains
Journal name Molecular Biosystems   Check publisher's open access policy
ISSN 1742-206X
1742-2051
Publication date 2013-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1039/c2mb25300c
Open Access Status Not Open Access
Volume 9
Issue 3
Start page 330
End page 338
Total pages 9
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2014
Language eng
Abstract Membrane microdomains such as lipid rafts and caveolae regulate a myriad of cellular functions including cell signalling, protein trafficking, cell viability, and cell movement. They have been implicated in diseases such as cancer, diabetes and Alzheimer's disease, highlighting the essential role they play in cell processes. Despite much research and debate on the size, composition and dynamics of membrane microdomains, the molecular mechanism(s) of their action remain poorly understood. Most studies have dealt solely with the content and properties of the membrane microdomain as an entity in itself. However, recent work shows that membrane microdomain disruption has wide ranging effects on other subcellular compartments, and the cell as a whole. Hence we propose that a systems approach incorporating many cellular attributes such as subcellular localisation is required in order to understand the global impact of microdomains on cell function. Although analysis of sub-proteome changes already provides additional insight, we further propose biological network analysis of functional proteomics data to capture effects at the systems level. In this review, we highlight the use of protein-protein interactions networks and mixed networks to portray and visualize the relationships between proteins within and between subcellular fractions. Such a systems analysis will be required to improve our understanding of the full cellular function of membrane microdomains.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
UQ Diamantina Institute Publications
 
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