Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study

Georgiou-Karistianis, N., Gray, M. A., Dominguez D, J. F., Dymowski, A. R., Bohanna, I., Johnston, L. A., Churchyard, A., Chua, P., Stout, J. C. and Egan, G. F. (2013) Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study. Neurobiology of Disease, 51 82-92. doi:10.1016/j.nbd.2012.10.001


Author Georgiou-Karistianis, N.
Gray, M. A.
Dominguez D, J. F.
Dymowski, A. R.
Bohanna, I.
Johnston, L. A.
Churchyard, A.
Chua, P.
Stout, J. C.
Egan, G. F.
Title Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study
Journal name Neurobiology of Disease   Check publisher's open access policy
ISSN 0969-9961
1095-953X
Publication date 2013-03
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.nbd.2012.10.001
Open Access Status
Volume 51
Start page 82
End page 92
Total pages 11
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2013
Language eng
Abstract We investigated two measures of neural integrity, T1-weighted volumetric measures and diffusion tensor imaging (DTI), and explored their combined potential to differentiate pre-diagnosis Huntington's disease (pre-HD) individuals from healthy controls. We applied quadratic discriminant analysis (QDA) to discriminate pre-HD individuals from controls and we utilised feature selection and dimension reduction to increase the robustness of the discrimination method. Thirty six symptomatic HD (symp-HD), 35 pre-HD, and 36 control individuals participated as part of the IMAGE-HD study and underwent T1-weighted MRI, and DTI using a Siemens 3. Tesla scanner. Volume and DTI measures [mean diffusivity (MD) and fractional anisotropy (FA)] were calculated for each group within five regions of interest (ROI; caudate, putamen, pallidum, accumbens and thalamus). QDA was then performed in a stepwise manner to differentiate pre-HD individuals from controls, based initially on unimodal analysis of motor or neurocognitive measures, or on volume, MD or FA measures from within the caudate, pallidum and putamen. We then tested for potential improvements to this model, by examining multi-modal MRI classifications (volume, FA and MD), and also included motor and neurocognitive measures, and additional brain regions (i.e., accumbens and thalamus). Volume, MD and FA differed across the three groups, with pre-HD characterised by significant volumetric reductions and increased FA within caudate, putamen and pallidum, relative to controls. The QDA results demonstrated that the differentiation of pre-HD from controls was highly accurate when both volumetric and diffusion data sets from basal ganglia (BG) regions were used. The highest discriminative accuracy however was achieved in a multi-modality approach and when including all available measures: motor and neurocognitive scores and multi-modal MRI measures from the BG, accumbens and thalamus. Our QDA findings provide evidence that combined multi-modal imaging measures can accurately classify individuals up to 15. years prior to onset when therapeutic intervention is likely to have maximal effects in slowing the trajectory of disease development.
Keyword Huntington's disease
T1-weighted volume
Mean diffusivity
Fractional anisotropy
Quadratic discriminant function analysis
Magnetic resonance imaging
Diffusion weighted imaging
Multivariate classification
Basal ganglia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 13 October 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Centre for Advanced Imaging Publications
 
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