Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

Kelemen, Linda E., Bandera, Elisa V., Terry, Kathryn L., Rossing, Mary Anne, Brinton, Louise A., Doherty, Jennifer A., Ness, Roberta B., Kjaer, Susanne Kruger, Chang-Claude, Jenny, Koebel, Martin, Lurie, Galina, Thompson, Pamela J., Carney, Michael E., Moysich, Kirsten, Edwards, Robert, Bunker, Clare, Jensen, Allan, Hogdall, Estrid, Cramer, Daniel W., Vitonis, Allison F., Olson, Sara H., King, Melony, Chandran, Urmila, Lissowska, Jolanta, Garcia-Closas, Montserrat, Yang, Hannah, Webb, Penelope M., Schildkraut, Joellen M., Goodman, Marc T. and Risch, Harvey A. (2013) Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium. BMC Cancer, 13 28: 1-12. doi:10.1186/1471-2407-13-28


Author Kelemen, Linda E.
Bandera, Elisa V.
Terry, Kathryn L.
Rossing, Mary Anne
Brinton, Louise A.
Doherty, Jennifer A.
Ness, Roberta B.
Kjaer, Susanne Kruger
Chang-Claude, Jenny
Koebel, Martin
Lurie, Galina
Thompson, Pamela J.
Carney, Michael E.
Moysich, Kirsten
Edwards, Robert
Bunker, Clare
Jensen, Allan
Hogdall, Estrid
Cramer, Daniel W.
Vitonis, Allison F.
Olson, Sara H.
King, Melony
Chandran, Urmila
Lissowska, Jolanta
Garcia-Closas, Montserrat
Yang, Hannah
Webb, Penelope M.
Schildkraut, Joellen M.
Goodman, Marc T.
Risch, Harvey A.
Title Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium
Journal name BMC Cancer   Check publisher's open access policy
ISSN 1471-2407
Publication date 2013-01-22
Sub-type Article (original research)
DOI 10.1186/1471-2407-13-28
Open Access Status DOI
Volume 13
Issue 28
Start page 1
End page 12
Total pages 12
Place of publication United Kingdom
Publisher BioMed Central
Collection year 2014
Language eng
Formatted abstract
Background Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations.

Methods We pooled data from 12 case-control studies in the Ovarian Cancer Association Consortium comprising 5,342 OC cases, 1,455 borderline tumors and 10,358 controls with quantitative information on recent alcohol intake to estimate odds ratios (OR) and 95% confidence intervals (CI) according to frequencies of average daily intakes of beer, wine, liquor and total alcohol.

Results Total alcohol intake was not associated with all OC: consumption of >3 drinks per day compared to none, OR=0.92, 95% CI=0.76-1.10, P trend=0.27. Among beverage types, a statistically non-significant decreased risk was observed among women who consumed >8 oz/d of wine compared to none (OR=0.83, 95% CI=0.68-1.01, P trend=0.08). This association was more apparent among women with clear cell OC (OR, 0.43; 95% CI, 0.22-0.83; P trend=0.02), although based on only 10 cases and not statistically different from the other histologic types (P value for statistical heterogeneity between histologic types = 0.09). Statistical heterogeneity of the alcohol- and wine-OC associations was seen among three European studies, but not among eight North American studies. No statistically significant associations were observed in separate analyses evaluating risk with borderline tumors of serous or mucinous histology. Smoking status did not significantly modify any of the associations.

Conclusions We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community.
Keyword Food frequency questionnaire
Oral-contraceptive use
Life-style factors
Postmenopausal women
Cigarette-smoking
Hormone-therapy
Cell carcinoma
IGF-1
Metaanalysis
Hereditary
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
 
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