Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease

Yates, P. A., Sirisriro, R., Villemagne, V. L., Farquharson, S., Masters, C. L., Rowe, C. C., AIBL Research Group and Salvado, Olivier (2011) Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease. Neurology, 77 1: 48-54. doi:10.1212/WNL.0b013e318221ad36


Author Yates, P. A.
Sirisriro, R.
Villemagne, V. L.
Farquharson, S.
Masters, C. L.
Rowe, C. C.
AIBL Research Group
Salvado, Olivier
Title Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease
Journal name Neurology   Check publisher's open access policy
ISSN 0028-3878
1526-632X
Publication date 2011-07
Sub-type Article (original research)
DOI 10.1212/WNL.0b013e318221ad36
Volume 77
Issue 1
Start page 48
End page 54
Total pages 7
Place of publication Philadelphia, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Objectives: Incidental cerebral microhemorrhage (MH) is frequently found in older individuals scanned with susceptibility-weighted MRI (SWI) or gradient-recalled echo MRI. MH have been linked with [beta]-amyloid (A[beta]) deposition using 11C-Pittsburgh compound B (PiB) PET in Alzheimer disease (AD) and cerebral amyloid angiopathy (CAA). We hypothesized that A[beta] deposition in asymptomatic elderly individuals is associated with lobar MH (LMH).

Methods:
This was a cross-sectional study of 84 elderly healthy controls (HC), 28 subjects with mild cognitive impairment (MCI), and 26 subjects with probable AD who underwent 3-T SWI and 11C-PiB PET. 11C-PiB cortical binding was quantified normalized to cerebellar cortex (standardized uptake value ratio [SUVR]) and scans classified as positive (PiB+) or negative (PiB-) by visual inspection. MH were manually counted and categorized by region and as lobar or nonlobar.

Results: LMH were present in 30.8% of AD, 35.7% of MCI, and 19.1% of HC. The prevalence of LMH among PiB+ subjects was similar, regardless of clinical classification (AD 30.8%, MCI 38.9%, HC 41.4%, p > 0.7). HC with LMH had significantly higher mean neocortical SUVR (1.7 ± 0.5) than HC without LMH (1.3 ± 0.3, p ± 0.01). In HC, there was a positive correlation between number of LMH and SUVR, and between LMH and age. In HC, PiB+ (odds ratio [OR] 7.3, 95% confidence interval [CI] 1.6–33.7, p = 0.01) and age (OR 1.2, 95% CI 1.03–1.3, p = 0.02) both independently predicted the occurrence of LMH using logistic regression.

Conclusion: Asymptomatic A[beta] deposition in older adults is strongly associated with LMH.
Keyword Pittsburgh compound-B
Recurrent intracerebral hemorrhage
Memory clinic population
Acute ischemic-stroke
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Information Technology and Electrical Engineering Publications
 
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