Dendritic cells and multiple sclerosis: disease, tolerance and therapy

Mohammad, G. Mohammad, Hassanpour, Masoud, Tsai, Vicky W. W., Li, Hui, Ruitenberg, Marc J., Booth, David R., Serrats, Jordi, Hart, Prue H., Symonds, Geoffrey P., Sawchenko, Paul E., Breit, Samuel N. and Brown, David A. (2013) Dendritic cells and multiple sclerosis: disease, tolerance and therapy. International Journal of Molecular Sciences, 14 1: 547-562. doi:10.3390/ijms14010547


Author Mohammad, G. Mohammad
Hassanpour, Masoud
Tsai, Vicky W. W.
Li, Hui
Ruitenberg, Marc J.
Booth, David R.
Serrats, Jordi
Hart, Prue H.
Symonds, Geoffrey P.
Sawchenko, Paul E.
Breit, Samuel N.
Brown, David A.
Title Dendritic cells and multiple sclerosis: disease, tolerance and therapy
Journal name International Journal of Molecular Sciences   Check publisher's open access policy
ISSN 1422-0067
Publication date 2013-01
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/ijms14010547
Open Access Status DOI
Volume 14
Issue 1
Start page 547
End page 562
Total pages 16
Place of publication Basel, Switzerland
Publisher M D P I AG
Collection year 2013
Language eng
Formatted abstract
Multiple sclerosis (MS) is a devastating neurological disease that predominantly affects young adults resulting in severe personal and economic impact. The majority of therapies for this disease were developed in, or are beneficial in experimental autoimmune encephalomyelitis (EAE), the animal model of MS. While known to target adaptive anti-CNS immune responses, they also target, the innate immune arm. This mini-review focuses on the role of dendritic cells (DCs), the professional antigen presenting cells of the innate immune system. The evidence for a role for DCs in the appropriate regulation of anti-CNS autoimmune responses and their role in MS disease susceptibility and possible therapeutic utility are discussed. Additionally, the current controversy regarding the evidence for the presence of functional DCs in the normal CNS is reviewed. Furthermore, the role of CNS DCs and potential routes of their intercourse between the CNS and cervical lymph nodes are considered. Finally, the future role that this nexus between the CNS and the cervical lymph nodes might play in site directed molecular and cellular therapy for MS is outlined.
Keyword Multiple sclerosis (MS)
Endritic cell
Experimental autoimmune encephalomyelitis
Cervical lymph node
Molecular therapy
Cellular therapy
Site directed local therapy
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
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