The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala

Long, Haixia, Liu, Bing, Hou, Bing, Wang, Chao, Li, Jin, Qin, Wen, Wang, Dawei, Zhou, Yuan, Kendrick, Keith M., Yu, Chunshui and Jiang, Tianzi (2013) The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala. Neuroscience Bulletin, 29 1: 4-15. doi:10.1007/s12264-013-1299-x


Author Long, Haixia
Liu, Bing
Hou, Bing
Wang, Chao
Li, Jin
Qin, Wen
Wang, Dawei
Zhou, Yuan
Kendrick, Keith M.
Yu, Chunshui
Jiang, Tianzi
Title The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala
Journal name Neuroscience Bulletin   Check publisher's open access policy
ISSN 1673-7067
1995-8218
Publication date 2013-02
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s12264-013-1299-x
Volume 29
Issue 1
Start page 4
End page 15
Total pages 12
Place of publication Shanghai, China
Publisher Zhongguo Kexueyuan Shanghai Shengming Kexue Yanjiuyuan
Collection year 2014
Language eng
Formatted abstract
The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n = 233). In contrast to findings in Caucasians, we found that long-allele (L) carriers had higher anxiety scores. In another group (n = 64) experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex (PFC), which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in generelated studies and their potential clinical applications.
Keyword Functional and anatomical connectivity
Amygdala
Prefrontal Cortex
Han Chinese
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
Centre for Advanced Imaging Publications
 
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