Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasites

Cestari, Igor, Evans-Osses, Ingrid, Schlapbach, Luregn J., de Messias-Reason, Iara and Ramirez, Marcel I. (2013) Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasites. Molecular Immunology, 53 4: 328-334. doi:10.1016/j.molimm.2012.08.015


Author Cestari, Igor
Evans-Osses, Ingrid
Schlapbach, Luregn J.
de Messias-Reason, Iara
Ramirez, Marcel I.
Title Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasites
Journal name Molecular Immunology   Check publisher's open access policy
ISSN 0161-5890
1872-9142
Publication date 2013-04
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.molimm.2012.08.015
Open Access Status
Volume 53
Issue 4
Start page 328
End page 334
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2014
Language eng
Formatted abstract
Studies in the past decade have demonstrated a crucial role for the complement lectin pathway in host defence against protozoan microbes. Recognition of pathogen surface molecules by mannan-binding lectin and ficolins revealed new mechanisms of innate immune defence and a diversity of parasite strategies of immune evasion. In the present review, we will discuss the current knowledge of: (1) the molecular mechanism of lectin pathway activation by trypanosomes; (2) the mechanisms of complement evasion by trypanosomes; and (3) host genetic deficiencies of complement lectin pathway factors that contribute to infection susceptibility and disease progression. This review will focus on trypanosomatids, the parasites that cause Chagas disease, leishmaniasis and sleeping sickness (African trypanosomiasis).
Keyword Complement system
Lectin pathway
Chagas disease
Trypanosomiasis
T. cruzi
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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