Off-pump coronary artery bypass surgery induces prolonged alterations to host neutrophil physiology

Edelman, J. James B., Fung, Yoke Lin, Pennings, Gabrielle J., Reddel, Caroline J., Bannon, Paul G., Bayfield, Matthew S., Kritharides, Leonard, Fraser, John F. and Vallely, Michael P. (2013) Off-pump coronary artery bypass surgery induces prolonged alterations to host neutrophil physiology. Shock, 39 2: 149-154. doi:10.1097/SHK.0b013e31827c2aba

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Author Edelman, J. James B.
Fung, Yoke Lin
Pennings, Gabrielle J.
Reddel, Caroline J.
Bannon, Paul G.
Bayfield, Matthew S.
Kritharides, Leonard
Fraser, John F.
Vallely, Michael P.
Title Off-pump coronary artery bypass surgery induces prolonged alterations to host neutrophil physiology
Journal name Shock   Check publisher's open access policy
ISSN 1073-2322
Publication date 2013-02
Year available 2013
Sub-type Article (original research)
DOI 10.1097/SHK.0b013e31827c2aba
Volume 39
Issue 2
Start page 149
End page 154
Total pages 6
Place of publication Baltimore, MD, United States
Publisher Lippincott Williams & Wilkins
Collection year 2014
Language eng
Abstract Persistent alteration to host polymorphonuclear cell (PMN) physiology has been demonstrated after cardiac surgery performed with cardiopulmonary bypass (CPB). However, to date, PMN physiology and function beyond the first 24 h have not been investigated after cardiac surgery performed without CPB (off-pump coronary artery bypass grafting [OPCAB]). Blood samples of 15 patients were collected preoperatively and on days 1, 3, and 5 after OPCAB. Expression of CD11b, CD18, CBRM1/5, and CD62L were assessed by flow cytometry under resting conditions and after stimulation with formyl methionyl-leucyl-phenylalanine (fMLF), and respiratory burst activity was also measured. Under resting conditions, PMN CD11b, CBRM1/5, and CD62L expressions were minimally altered by surgery. Compared with the response of preoperative PMNs, PMNs assayed on days 3 and 5 after OPCAB demonstrated a significantly blunted increase in the expression of CD11b and CBRM1/5 after fMLF, significantly diminished shedding of CD62L in response to platelet-activating factor and fMLF, and diminished superoxide production after stimulation on day 3. The alteration of PMN function after OPCAB implies that cardiac surgical trauma without CPB directly modulates host PMN physiology.
Keyword Neutrophils
Off-pump coronary artery bypass grafting
Systemic inflammatory response syndrome
Cardiopulmonary bypass
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 03 Mar 2013, 00:30:53 EST by System User on behalf of Anaesthesiology and Critical Care - RBWH