Synthesis of 4-methylthiophenylpropylamine and the evaluation of its interaction with different amine oxidases

Gallardo-Godoy, Alejandra, Hernandez, Mar, Sanz, Elisenda and Unzeta, Mercedes (2004) Synthesis of 4-methylthiophenylpropylamine and the evaluation of its interaction with different amine oxidases. Bioorganic & Medicinal Chemistry, 12 1: 273-279. doi:10.1016/j.bmc.2003.10.007


Author Gallardo-Godoy, Alejandra
Hernandez, Mar
Sanz, Elisenda
Unzeta, Mercedes
Title Synthesis of 4-methylthiophenylpropylamine and the evaluation of its interaction with different amine oxidases
Journal name Bioorganic & Medicinal Chemistry   Check publisher's open access policy
ISSN 0968-0896
1464-3391
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1016/j.bmc.2003.10.007
Volume 12
Issue 1
Start page 273
End page 279
Total pages 7
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Language eng
Formatted abstract
A new molecule, the 4-methyl-thio-phenyl-propylamine (PrNH2) was synthesized and its biological interaction with different amine oxidases such as semicarbazide sensitive amine oxidase (SSAO) [E.C.1.4.3.6], and monoamine oxidase [E.C.1.4.3.4] under its two isoforms, MAO A and MAO B, has been assessed. The substrate specifities of MAO and SSAO overlap to some extent. In this context, the search of new molecules, able to discriminate between these different amine oxidases is very important as it will allow greater elucidation of the SSAO's role in physiological and pathological conditions. We report for the first time, the synthesis and evaluation of a new molecule which has a high affinity towards the SSAO family of enzymes, more so than previously described and furthermore an ability to discriminate between the different amine oxidases.
Keyword 4-Methyl-thio-phenyl-propylamine
Amine oxidases inhibitor
Biological evaluation
MAO
SSAO
Synthesis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 02 Mar 2013, 00:11:27 EST by Susan Allen on behalf of Institute for Molecular Bioscience