Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness

Ferguson, Patricia E., Gilroy, Nicole M., Faux, Cassandra E., Mackay, Ian M., Sloots, Theo P., Nissen, Michael D., Dwyer, Dominic E. and Sorrell, Tania C. (2013) Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness. Journal of Clinical Virology, 56 3: 255-259. doi:10.1016/j.jcv.2012.11.010

Author Ferguson, Patricia E.
Gilroy, Nicole M.
Faux, Cassandra E.
Mackay, Ian M.
Sloots, Theo P.
Nissen, Michael D.
Dwyer, Dominic E.
Sorrell, Tania C.
Title Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness
Journal name Journal of Clinical Virology   Check publisher's open access policy
ISSN 1386-6532
Publication date 2013-03
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.jcv.2012.11.010
Open Access Status
Volume 56
Issue 3
Start page 255
End page 259
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Background: A previously unidentified species of human rhinovirus, HRV-C, was described in 2006 in association with lower respiratory tract infection (LRTI). Features of infection in immunosuppressed adults are poorly characterised.

Objectives: This study aims to determine the epidemiology of HRV-C in haematopoietic stem cell transplant (HSCT) recipients in a single centre.

Study design: A prospective cohort study of all HSCT recipients admitted to Westmead Hospital, Westmead, Australia from 1 July 2005 to 30 September 2007 was undertaken. Nose/throat samples were collected from all patients at the time of admission and patients developing pre-defined symptoms and/or signs of respiratory infection during the admission. Samples were processed and tested for rhinoviruses and 14 other respiratory viruses using nucleic acid-based methods, immunofluorescence and culture. HRV genotyping was performed by sequencing a region of the rhinovirus 5' untranslated region (UTR). Clinical data on each episode were collected prospectively.

Results: HRVs were identified in 24 episodes: 8% of 299 episodes of clinically- defined respiratory infections and 39% of 61 episodes in which respiratory viruses were detected. HRV-C was most frequent (HRV-C: nine, HRV-A: eight and HRV-B: two). Seven episodes of HRV-C, five with pneumonia, occurred within 100 days of HSCT. Co-pathogens were frequent.

Conclusions: The newly described HRV-C was the most common rhinovirus group detected in HSCT recipients with respiratory infection, with co-pathogens being frequent. Further research is required to understand the activity and pathogenicity of this virus in HSCT recipients.
Keyword Rhinovirus
Respiratory virus
Haematopoietic stem cell transplant
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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