Outcome at two years of age in a Swiss national cohort of extremely preterm infants born between 2000 and 2008

Schlapbach, Luregn J., Adams, Mark, Proietti, Elena, Aebischer, Maude, Grunt, Sebastian, Borradori-Tolsa, Cristina, Bickle-Graz, Myriam, Bucher, Hans Ulrich, Latal, Beatrice and Natalucci, Giancarlo (2012) Outcome at two years of age in a Swiss national cohort of extremely preterm infants born between 2000 and 2008. Bmc Pediatrics, 12 198.1-198.12. doi:10.1186/1471-2431-12-198

Author Schlapbach, Luregn J.
Adams, Mark
Proietti, Elena
Aebischer, Maude
Grunt, Sebastian
Borradori-Tolsa, Cristina
Bickle-Graz, Myriam
Bucher, Hans Ulrich
Latal, Beatrice
Natalucci, Giancarlo
Title Outcome at two years of age in a Swiss national cohort of extremely preterm infants born between 2000 and 2008
Journal name Bmc Pediatrics   Check publisher's open access policy
ISSN 1471-2431
Publication date 2012-12
Year available 2012
Sub-type Article (original research)
DOI 10.1186/1471-2431-12-198
Open Access Status DOI
Volume 12
Start page 198.1
End page 198.12
Total pages 12
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2013
Language eng
Formatted abstract
While survival rates of extremely preterm infants have improved over the last decades, the incidence of neurodevelopmental disability (ND) in survivors remains high. Representative current data on the severity of disability and of risk factors associated with poor outcome in this growing population are necessary for clinical guidance and parent counselling.


Prospective longitudinal multicentre cohort study of preterm infants born in Switzerland between 240/7 and 276/7 weeks gestational age during 2000–2008. Mortality, adverse outcome (death or severe ND) at two years, and predictors for poor outcome were analysed using multilevel multivariate logistic regression. Neurodevelopment was assessed using Bayley Scales of Infant Development II. Cerebral palsy was graded after the Gross Motor Function Classification System.

Of 1266 live born infants, 422 (33%) died. Follow-up information was available for 684 (81%) survivors: 440 (64%) showed favourable outcome, 166 (24%) moderate ND, and 78 (11%) severe ND. At birth, lower gestational age, intrauterine growth restriction and absence of antenatal corticosteroids were associated with mortality and adverse outcome (p < 0.001). At 360/7 weeks postmenstrual age, bronchopulmonary dysplasia, major brain injury and retinopathy of prematurity were the main predictors for adverse outcome (p < 0.05). Survival without moderate or severe ND increased from 27% to 39% during the observation period (p = 0.02).

In this recent Swiss national cohort study of extremely preterm infants, neonatal mortality was determined by gestational age, birth weight, and antenatal corticosteroids while neurodevelopmental outcome was determined by the major neonatal morbidities. We observed an increase of survival without moderate or severe disability.
Keyword Development
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 26 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 17 Feb 2013, 00:50:09 EST by System User on behalf of School of Medicine