Expression of metallothionein isoforms in peripheral blood leukocytes from Thai population residing in cadmium-contaminated areas

Boonprasert, Kanyarat, Ruengweerayut, Ronnatrai, Aunpad, Ratchaneewan, Satarug, Soisungwan and Na-Bangchang, Kesara (2012) Expression of metallothionein isoforms in peripheral blood leukocytes from Thai population residing in cadmium-contaminated areas. Environmental Toxicology and Pharmacology, 34 3: 935-940. doi:10.1016/j.etap.2012.08.002


Author Boonprasert, Kanyarat
Ruengweerayut, Ronnatrai
Aunpad, Ratchaneewan
Satarug, Soisungwan
Na-Bangchang, Kesara
Title Expression of metallothionein isoforms in peripheral blood leukocytes from Thai population residing in cadmium-contaminated areas
Journal name Environmental Toxicology and Pharmacology   Check publisher's open access policy
ISSN 1382-6689
1872-7077
Publication date 2012-11
Sub-type Article (original research)
DOI 10.1016/j.etap.2012.08.002
Volume 34
Issue 3
Start page 935
End page 940
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2013
Language eng
Formatted abstract
Metallothionein (MT) is a group of proteins with high cadmium (Cd) affinity and with a potential role in Cd transportation and detoxification. The aim of the present study was to investigate the relationship between MT (MT-1A, MT-2A, and MT-3 isoforms) gene expression level in peripheral blood leukocytes and Cd-associated renal injury in non-occupational exposed Thai population. The study was conducted in adult subjects residing in Cd-contaminated areas of Mae Sot District, Thailand. The basal levels of MT-1A, MT-2A, and MT-3 mRNA expression were determined in leukocytes by quantitative RT-PCR. MT-1A and MT-2A expressions, particularly MT-1A, were found to be significantly increased with elevated levels of blood and urinary Cd levels. In subjects with high urinary Cd levels, negative correlations between MT-1A and microalbumin, and between MT-2A and β2-MG, were observed. These results suggest that MT gene expression may reflect susceptibility of the exposed population to Cd-induced renal dysfunction. MT-1A mRNA expression in leukocytes might be developed as a potential biomarker of Cd exposure and Cd-induced renal dysfunction.
Keyword Metallothionein
Cadmium
Renal dysfunction biomarkers
Leukocytes
Gene expression
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
National Research Centre for Environmental Toxicology Publications
 
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