Probiotics: a potential role in the prevention of gestational diabetes?

Barrett, Helen L., Callaway, Leonie K. and Nitert, Marloes Dekker (2012) Probiotics: a potential role in the prevention of gestational diabetes?. Acta Diabetologica, 49 S1-S13. doi:10.1007/s00592-012-0444-8

Author Barrett, Helen L.
Callaway, Leonie K.
Nitert, Marloes Dekker
Title Probiotics: a potential role in the prevention of gestational diabetes?
Journal name Acta Diabetologica   Check publisher's open access policy
ISSN 0940-5429
Publication date 2012-12
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00592-012-0444-8
Volume 49
Start page S1
End page S13
Total pages 13
Place of publication Milan, Italy
Publisher Springer Italia Srl
Collection year 2013
Language eng
Abstract The gut microbiome has a complex relationship with host metabolism and immune function. Host health and diet influence the composition of the gut microbiome, and conversely, different microbiome compositions influence host metabolism. Gestational diabetes mellitus is increasingly common and has serious implications for maternal and foetal health both during pregnancy and later in life. To date, clinical trials of exercise and dietary interventions to prevent the onset of gestational diabetes have had heterogeneous results and have proven disappointingly difficult. Alternative prevention strategies of gestational diabetes mellitus need to be considered and trialled in a placebo-controlled manner in combination with dietary and behavioural measures. One such potential preventative therapy is probiotic supplementation, that is, ingestion of specific bacterial strains with beneficial effects on the host. Probiotic supplements have been shown to improve metabolism by increasing host insulin sensitivity, cholesterol metabolism and also have a beneficial effect on the immune system. This discussion paper examines the evidence for the influence of the gut microbiome on host metabolism and the potential metabolic impact of probiotic supplementation, with particular regard for the evidence surrounding a possible use of probiotic supplements for the prevention of gestational diabetes. Probiotics offer the tantalising possibility of a feasible intervention for the prevention of gestational diabetes and improvement of metabolic syndromes, but there is a pressing need for further studies of the mechanisms underlying the apparent metabolic benefits and for the use of randomised controlled trials to allow examination of the effectiveness of probiotic supplementation in this setting.
Keyword Gestational diabetes mellitus
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 21 November 2012.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
School of Medicine Publications
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