Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy

Kim, Tae Hwan, Borges, Karin, Petrou, Steven and Reid, Christopher A. (2013) Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy. Epilepsy Research, 103 1: 101-105. doi:10.1016/j.eplepsyres.2012.09.016


Author Kim, Tae Hwan
Borges, Karin
Petrou, Steven
Reid, Christopher A.
Title Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy
Journal name Epilepsy Research   Check publisher's open access policy
ISSN 0920-1211
1872-6844
Publication date 2013-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.eplepsyres.2012.09.016
Volume 103
Issue 1
Start page 101
End page 105
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2013
Language eng
Formatted abstract
Triheptanoin is a triglyceride containing heptanoate, an odd-chained medium fatty acid that is metabolized to produce propionyl-CoA and subsequently C4 intermediates of the citric acid cycle and therefore capable of anaplerosis. These metabolic products are believed to underlie triheptanoin's anticonvulsant effects in rodent seizure models. Here we investigate the anticonvulsive effects of oral triheptanoin in a syndrome-specific genetic mouse model of generalized epilepsy based on the GABAAγ2(R43Q) mutation. Mice were fed a diet supplemented with triheptanoin from weaning for three weeks prior to electrocortical recordings. Occurrence and durations of spike and wave discharges (SWDs) were measured. Triheptanoin did not alter body weight or basal blood glucose levels suggesting that it was well tolerated. Triheptanoin supplementation halved the time spent in seizures due to a reduction in both SWD occurrence and duration. An injection of insulin was used to reduce blood glucose, a metabolic stress known to precipitate seizures in the GABAAγ2(R43Q) mouse. The reduction in seizure count was also evident following insulin induced hypoglycemia with the triheptanoin treated group having significantly less SWDs than control animals under similar low blood glucose conditions. In summary, triheptanoin may be an effective and well tolerated dietary therapy for generalized epilepsy
Keyword Absence seizures
Diet
Genetic models
Ketogenic
Spike and wave discharge
Triheptanoin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 26 November 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
 
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Created: Thu, 14 Feb 2013, 11:10:43 EST by Dr Karin Borges on behalf of School of Biomedical Sciences