Transforming growth factor-beta and abdominal aortic aneurysms

Wang, Yutang, Krishna, Smriti, Walker, Philip J., Norman, Paul and Golledge, Jonathan (2013) Transforming growth factor-beta and abdominal aortic aneurysms. Cardiovascular Pathology, 22 2: 126-132. doi:10.1016/j.carpath.2012.07.005


Author Wang, Yutang
Krishna, Smriti
Walker, Philip J.
Norman, Paul
Golledge, Jonathan
Title Transforming growth factor-beta and abdominal aortic aneurysms
Formatted title
Transforming growth factor-β and abdominal aortic aneurysms
Journal name Cardiovascular Pathology   Check publisher's open access policy
ISSN 1054-8807
1879-1336
Publication date 2013-03
Sub-type Article (original research)
DOI 10.1016/j.carpath.2012.07.005
Open Access Status
Volume 22
Issue 2
Start page 126
End page 132
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Abdominal aortic aneurysms (AAAs) are common problems in aged people which can be associated with severe complications including aortic rupture and death. Transforming growth factor-β (TGFβ) has been implicated as causative in the development of thoracic aortic aneurysms (TAAs). In contrast, current evidence suggests TGFβ inhibits AAA development. Polymorphisms in the TGFβ signaling components are associated with AAA in some human population studies. In experimental animals TGFβ protects against AAA formation, progression and rupture. In animal models of AAA TGFβ decreases aortic inflammatory cell infiltration, extracellular matrix degradation, and vascular smooth muscle cell apoptosis, all factors implicated in AAA pathogenesis. The TGFβ signaling pathway may provide a therapeutic target for AAA although better clarity is needed regarding the distinct roles of TGFβ in TAA and AAA.
Keyword Abdominal aortic aneurysm
Extracellular matrix
Matrix metalloproteinase
Transforming growth factor-β
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Thu, 14 Feb 2013, 10:22:54 EST by Mrs Maureen Pollard on behalf of Paediatrics & Child Health - RBWH