Mirtazapine in veterinary medicine a pharmacological rationale for its application in chronic pain

Giogi, Mario and Owen, Helen (2012) Mirtazapine in veterinary medicine a pharmacological rationale for its application in chronic pain. American Journal of Animal and Veterinary Science, 7 1: 42-47. doi:10.3844/ajavsp.2012.42.47

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Author Giogi, Mario
Owen, Helen
Title Mirtazapine in veterinary medicine a pharmacological rationale for its application in chronic pain
Journal name American Journal of Animal and Veterinary Science   Check publisher's open access policy
ISSN 1557-4555
1557-4563
Publication date 2012-01-01
Year available 2012
Sub-type Article (original research)
DOI 10.3844/ajavsp.2012.42.47
Open Access Status DOI
Volume 7
Issue 1
Start page 42
End page 47
Total pages 6
Place of publication New York, NY, United States
Publisher Science Publications
Collection year 2013
Language eng
Formatted abstract
Problem statement: Many recent studies have shown that antidepressant agents have analgesic effects in addition to their intended primary actions. The Tricyclic Antidepressants (TCAs) have been recognized as an effective first-line treatment of human neuropathic pain but unfortunately they display a wide range of side effects. Recent studies have shown that Selective Serotonin Reuptake Inhibitors (SSRI) also have potential analgesic effects, albeit of a lower potency compared with the TCAs. Despite this, there is a trend for their increased use, in place of TCAs, in the treatment of chronic pain. Mirtazapine, a SSRI has been recently investigated in the context of veterinary medicine. It has shown favourable pharmacokinetic profiles. Despite the fact that it has mainly been used for anorexia and as an antiemetic for veterinary patients thus far, it could be potentially useful for the treatment of a wide range of anxiety-related conditions and as an analgesic in chronic and cancerassociated pain, due to its effects on both the noradrenergic and serotonic system. Rationale for the use of mirtazapine in veterinary medicine is reviewed in light of previously published literature.

Conclusion/Recommendations: Mirtazapine is proposed as a potential analgesic for use in a multidrug analgesic regime in the context of veterinary medicine. Further studies need to be performed before it is implemented in clinical practice however.
Keyword Mirtazapine
Pain
SerotoninAnimals
SSRI
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Veterinary Science Publications
 
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Created: Thu, 14 Feb 2013, 02:35:13 EST by Dr Helen Owen on behalf of School of Veterinary Science