Treatment options for New Delhi metallo-beta-lactamase-harboring Enterobacteriaceae

Rogers, Benjamin A., Sidjabat, Hanna E., Silvey, Anna, Anderson, Tara L., Perera, Shalini, Li, Jian and Paterson, David L. (2013) Treatment options for New Delhi metallo-beta-lactamase-harboring Enterobacteriaceae. Microbial Drug Resistance, 19 2: 100-103. doi:10.1089/mdr.2012.0063

Author Rogers, Benjamin A.
Sidjabat, Hanna E.
Silvey, Anna
Anderson, Tara L.
Perera, Shalini
Li, Jian
Paterson, David L.
Title Treatment options for New Delhi metallo-beta-lactamase-harboring Enterobacteriaceae
Journal name Microbial Drug Resistance   Check publisher's open access policy
ISSN 1076-6294
Publication date 2013-03-26
Year available 2012
Sub-type Article (original research)
DOI 10.1089/mdr.2012.0063
Volume 19
Issue 2
Start page 100
End page 103
Total pages 4
Place of publication New Rochelle, NY, United States
Publisher Mary Ann Liebert
Collection year 2013
Language eng
Formatted abstract
The New Delhi metallo-β-lactamase gene (blaNDM-1) has emerged as a worldwide concern among isolates of Enterobacteriaceae. Its epidemiology is been strongly associated with travel and healthcare on the Indian Subcontinent. We report two cases of urinary tract infection with Enterobacteriaceae harboring a blaNDM-1. Both cases presented as infection in community-dwelling individuals in Australia and were associated with travel to the Indian Subcontinent. One isolate of Escherichia coli harbored the previously undescribed enzyme variant blaNDM-3, differing from blaNDM-1 by a single nonsynonymous SNP conferring a putative peptide sequence change at the 95th position (ASP→ASN). The second was an Enterobacter cloacae harboring blaNDM-1. Further genetic characterization included identification of additional β-lactamase and aminoglycoside resistance genes. Legacy antimicrobials were used for treatment. Oral therapy with nitrofurantoin was successful in one case, while combination of colistin and rifampicin was required in the second patient. Such infection, due to extensively drug-resistant pathogens, poses significant challenges in balancing the efficacy and toxicity of potential antimicrobial therapies.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
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Citation counts: TR Web of Science Citation Count  Cited 29 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 13 Feb 2013, 13:43:00 EST by Mrs Maureen Pollard on behalf of Paediatrics & Child Health - RBWH