Childhood intelligence is heritable, highly polygenic and associated with FNBP1L

Benyamin, B., St Pourcain, B., Davis, O. S., Davies, G., Hansell, N. K., Brion, M. J., Kirkpatrick, R. M., Cents, R. A. M., Franic, S., Miller, M. B., Haworth, C. M. A., Meaburn, E., Price, T. S., Evans, D. M., Timpson, N., Kemp, J., Ring, S., McArdle, W., Medland, S. E., Yang, J., Harris, S. E., Liewald, D. C., Scheet, P., Xiao, X., Hudziak, J. J., de Geus, E. J. C., Wellcome Trust Case Control Consortium 2 (WTCCC2), Jaddoe, V. W. V., Starr, J. M., Verhulst, F. C., Pennell, C., Tiemeier, H., Iacono, W. G., Palmer, L. J., Montgomery, G. W., Martin, N. G., Boomsma, D. I., Posthuma, D., McGue, M., Wright, M. J., Davey Smith, G., Deary, I. J., Plomin, R. and Visscher, P. M. (2014) Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Molecular Psychiatry, 19 2: 253-258. doi:10.1038/mp.2012.184

Author Benyamin, B.
St Pourcain, B.
Davis, O. S.
Davies, G.
Hansell, N. K.
Brion, M. J.
Kirkpatrick, R. M.
Cents, R. A. M.
Franic, S.
Miller, M. B.
Haworth, C. M. A.
Meaburn, E.
Price, T. S.
Evans, D. M.
Timpson, N.
Kemp, J.
Ring, S.
McArdle, W.
Medland, S. E.
Yang, J.
Harris, S. E.
Liewald, D. C.
Scheet, P.
Xiao, X.
Hudziak, J. J.
de Geus, E. J. C.
Wellcome Trust Case Control Consortium 2 (WTCCC2)
Jaddoe, V. W. V.
Starr, J. M.
Verhulst, F. C.
Pennell, C.
Tiemeier, H.
Iacono, W. G.
Palmer, L. J.
Montgomery, G. W.
Martin, N. G.
Boomsma, D. I.
Posthuma, D.
McGue, M.
Wright, M. J.
Davey Smith, G.
Deary, I. J.
Plomin, R.
Visscher, P. M.
Total Author Count Override 44
Title Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
Formatted title
Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1359-4184
Publication date 2014-02
Year available 2013
Sub-type Article (original research)
DOI 10.1038/mp.2012.184
Volume 19
Issue 2
Start page 253
End page 258
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing
Collection year 2014
Language eng
Formatted abstract
Intelligence in childhood, as measured by psychometric cognitive tests, is a strong predictor of many important life outcomes, including educational attainment, income, health and lifespan. Results from twin, family and adoption studies are consistent with general intelligence being highly heritable and genetically stable throughout the life course. No robustly associated genetic loci or variants for childhood intelligence have been reported. Here, we report the first genome-wide association study (GWAS) on childhood intelligence (age range 6–18 years) from 17 989 individuals in six discovery and three replication samples. Although no individual single-nucleotide polymorphisms (SNPs) were detected with genome-wide significance, we show that the aggregate effects of common SNPs explain 22–46% of phenotypic variation in childhood intelligence in the three largest cohorts (P=3.9 × 10−15, 0.014 and 0.028). FNBP1L, previously reported to be the most significantly associated gene for adult intelligence, was also significantly associated with childhood intelligence (P=0.003). Polygenic prediction analyses resulted in a significant correlation between predictor and outcome in all replication cohorts. The proportion of childhood intelligence explained by the predictor reached 1.2% (P=6 × 10−5), 3.5% (P=10−3) and 0.5% (P=6 × 10−5) in three independent validation cohorts. Given the sample sizes, these genetic prediction results are consistent with expectations if the genetic architecture of childhood intelligence is like that of body mass index or height. Our study provides molecular support for the heritability and polygenic nature of childhood intelligence. Larger sample sizes will be required to detect individual variants with genome-wide significance.
Keyword Intelligence
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 29 January 2013.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 44 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 12 Feb 2013, 17:09:25 EST by Debra McMurtrie on behalf of Queensland Brain Institute