A systematic review and meta-analysis of recovery in schizophrenia

Jääskeläinen, Erika, Juola, Pauliina, Hirvonen, Noora, McGrath, John J., Saha, Sukanta, Isohanni, Matti, Veijola, Juha and Miettunen, Jouko (2013) A systematic review and meta-analysis of recovery in schizophrenia. Schizophrenia Bulletin, 39 6: 1296-1306. doi:10.1093/schbul/sbs130

Author Jääskeläinen, Erika
Juola, Pauliina
Hirvonen, Noora
McGrath, John J.
Saha, Sukanta
Isohanni, Matti
Veijola, Juha
Miettunen, Jouko
Title A systematic review and meta-analysis of recovery in schizophrenia
Journal name Schizophrenia Bulletin   Check publisher's open access policy
ISSN 0586-7614
Publication date 2013-11
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1093/schbul/sbs130
Open Access Status
Volume 39
Issue 6
Start page 1296
End page 1306
Total pages 11
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2013
Language eng
Formatted abstract
Objective: Our primary aims were (a) to identify the proportion of individuals with schizophrenia and related psychoses who met recovery criteria based on both clinical and social domains and (b) to examine if recovery was associated with factors such as gender, economic index of sites, and selected design features of the study. We also examined if the proportions who met our definition of recovery had changed over time.

Method: A comprehensive search strategy was used to identify potential studies, and data were extracted for those that met inclusion criteria. The proportion who met our recovery criteria (improvements in both clinical and social domains and evidence that improvements in at least 1 of these 2 domains had persisted for at least 2 years) was extracted from each study. Meta-regression techniques were used to explore the association between the recovery proportions and the selected variables.

Results: We identified 50 studies with data suitable for inclusion. The median proportion (25%–75% quantiles) who met our recovery criteria was 13.5% (8.1%–20.0%). Studies from sites in countries with poorer economic status had higher recovery proportions. However, there were no statistically significant differences when the estimates were stratified according to sex, midpoint of intake period, strictness of the diagnostic criteria, duration of follow-up, or other design features.

Based on the best available data, approximately, 1 in 7 individuals with schizophrenia met our criteria for recovery. Despite major changes in treatment options in recent decades, the proportion of recovered cases has not increased.
Keyword Schizophrenia
Outcome studies
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First published online: 20 November 2012.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2013 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 63 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 12 Feb 2013, 16:00:18 EST by Debra McMurtrie on behalf of Queensland Brain Institute