Reduced rhinovirus-specific antibodies are associated with acute exacerbations of chronic obstructive pulmonary disease requiring hospitalisation

Yerkovich, Stephanie T., Hales, Belinda J., Carroll, Melanie L., Burel, Julie G., Towers, Michelle A., Smith, Daniel J., Thomas, Wayne R. and Upham, John W. (2012) Reduced rhinovirus-specific antibodies are associated with acute exacerbations of chronic obstructive pulmonary disease requiring hospitalisation. Bmc Pulmonary Medicine, 12 Article No.37: 37-1-37-7. doi:10.1186/1471-2466-12-37


Author Yerkovich, Stephanie T.
Hales, Belinda J.
Carroll, Melanie L.
Burel, Julie G.
Towers, Michelle A.
Smith, Daniel J.
Thomas, Wayne R.
Upham, John W.
Title Reduced rhinovirus-specific antibodies are associated with acute exacerbations of chronic obstructive pulmonary disease requiring hospitalisation
Journal name Bmc Pulmonary Medicine   Check publisher's open access policy
ISSN 1471-2466
Publication date 2012-07
Year available 2012
Sub-type Article (original research)
DOI 10.1186/1471-2466-12-37
Open Access Status DOI
Volume 12
Issue Article No.37
Start page 37-1
End page 37-7
Total pages 7
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2013
Language eng
Formatted abstract
Background: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are often linked to respiratory infections. However, it is unknown if COPD patients who experience frequent exacerbations have impaired humoral immunity. The aim of this study was to determine if antibodies specific for common respiratory pathogens are associated with AECOPD.

Methods: Plasma was obtained from COPD patients when clinically stable. AECOPD requiring hospitalisation were recorded. IgG1 antibodies to H. Influenzae outer membrane protein 6 (P6), pneumococcal surface protein C (PspC) and the VP1 viral capsid protein of rhinovirus were measured.

Results: COPD patients who had an AECOPD (n = 32) had significantly lower anti-VP1 IgG1 antibody levels when stable compared to COPD patients who did not have an AECOPD (n = 28, p = 0.024). Furthermore, the number of hospitalisations was inversely proportional to anti-VP1 antibody levels (r = -0.331, p = 0.011). In contrast, antibodies specific for P6 and PspC were present at similar concentrations between groups. Plasma IL-21, a cytokine important for B-cell development and antibody synthesis, was also lower in COPD patients who had an AECOPD, than in stable COPD patients (p = 0.046).

Conclusion: Deficient humoral immunity specific for rhinoviruses is associated with AECOPD requiring hospitalisation, and may partly explain why some COPD patients have an increased exacerbation risk following respiratory viral infections.
Keyword Respiratory Viruses
Copd
Mortality
Children
Asthma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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