Poly(glycerol-sebacate) bioelastomers-kinetics of step-growth reactions using Fourier Transform (FT)-Raman spectroscopy

Maliger, Raju, Halley, Peter J. and Cooper-White, Justin J. (2013) Poly(glycerol-sebacate) bioelastomers-kinetics of step-growth reactions using Fourier Transform (FT)-Raman spectroscopy. Journal of Applied Polymer Science, 127 5: 3980-3986. doi:10.1002/app.37719

Author Maliger, Raju
Halley, Peter J.
Cooper-White, Justin J.
Title Poly(glycerol-sebacate) bioelastomers-kinetics of step-growth reactions using Fourier Transform (FT)-Raman spectroscopy
Journal name Journal of Applied Polymer Science   Check publisher's open access policy
ISSN 0021-8995
Publication date 2013-03
Year available 2012
Sub-type Article (original research)
DOI 10.1002/app.37719
Volume 127
Issue 5
Start page 3980
End page 3986
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2013
Language eng
Formatted abstract
Kinetic studies of the esterification of glycerol (G) and sebacic acid (SA) at three molar ratios (0.6, 0.8, 1.0) and at three temperatures (120, 130, 140°C) to form poly(glycerol-sebacate) were performed and assessed using FT-Raman spectroscopy. The quantitative changes in the concentrations of carboxylic acid and ester groups within the forming bioelastomer were measured and the chemical rate constants (k) determined from the kinetic scheme were first-order, with respect to sebacic acid concentration. Increasing the reaction temperature by 20°C is noted to increase the chemical rate constant (k) by a factor of up to 4.5 and the total extent of conversion at early times for the molar ratios investigated. The activation energy (Ea) and the pre-exponential factor (A0) for these three stoichiometric ratios were calculated, which varied in accordance with the average functionality of the system. Under isothermal conditions, the chemical rate constant remained unchanged with an increase in the extent of the reaction (α) until a spontaneous transition resulted in the shift in the mechanism from kinetics to diffusion controlled. The Young's moduli of the PGS polymers were found to depend primarily on the average functionality of the system and the curing period. This investigation confirms the reaction mechanism for PGS polymer synthesis and shows the flexibility afforded to PGS properties and reaction times through varying the stoichiometric ratios of glycerol to sebacic acid.
Keyword Biomaterials
Biopolymers renewable polymers
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 24 May 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Engineering Publications
Australian Institute for Bioengineering and Nanotechnology Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 10 Feb 2013, 01:07:33 EST by System User on behalf of Aust Institute for Bioengineering & Nanotechnology