Effects of varying heptylamine and propionaldehyde plasma polymerization parameters on mesenchymal stem cell attachment

Sandstrom, Anne M., Jasieniak, Marek, Griesser, Hans J., Grondahl, Lisbeth and Cooper-White, Justin J. (2013) Effects of varying heptylamine and propionaldehyde plasma polymerization parameters on mesenchymal stem cell attachment. Plasma Processes and Polymers, 10 1: 19-28. doi:10.1002/ppap.201200009


Author Sandstrom, Anne M.
Jasieniak, Marek
Griesser, Hans J.
Grondahl, Lisbeth
Cooper-White, Justin J.
Title Effects of varying heptylamine and propionaldehyde plasma polymerization parameters on mesenchymal stem cell attachment
Journal name Plasma Processes and Polymers   Check publisher's open access policy
ISSN 1612-8850
1612-8869
Publication date 2013-01
Year available 2012
Sub-type Article (original research)
DOI 10.1002/ppap.201200009
Volume 10
Issue 1
Start page 19
End page 28
Total pages 10
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag GmbH and Co. KGaA
Collection year 2013
Language eng
Formatted abstract
This paper investigated the impacts of two deposition times (30 s, 60 s) and discharge powers (20 W, 50 W) on the resultant chemical and physical properties of plasma polymers (pp) formed using heptylamine (HA) or propionaldehyde (PA) monomers. Pinhole-free pp films were formed on all surfaces at deposition rates that varied according to both the time and power employed. XPS and ToF-SIMS analysis showed that power has a more of an effect than time on the chemical properties of the pp, which may be attributed to differences in monomer fragmentation and cross-linking. Mesenchymal stem cell (MSC) adhesion did not vary on the four different HApp surfaces, whereas a negative correlation between cell attachment and increasing plasma energy was observed on PApp surfaces. This suggests that the presence of oxygenated groups, particularly aldehyde and carboxylic groups, may have a dominant impact on MSC adhesion to these functional polymer substrates. Here, we examine the effects of power and time on the properties of the resulting heptylamine (HA) and propionaldehyde (PA) plasma polymers (pp). Whereas mesenchymal stem cell (MSC) adhesion to the various HApp was similar, a negative correlation was observed between MSC attachment and increasing plasma energy for PApp
Keyword Heptylamine
Plasma polymerization
Propionaldehyde
Stem cell attachment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 08 Feb 2013, 13:30:24 EST by Mrs Louise Nimwegen on behalf of Aust Institute for Bioengineering & Nanotechnology