Antigenic variation in the bovine ephemeral fever virus glycoprotein

Cybinski, D. H. and St George, T. D. (1993). Antigenic variation in the bovine ephemeral fever virus glycoprotein. In: T. D. St George, M. F. Uren, P. L. Young and D. Hoffmann, Bovine Ephemeral Fever and Related Rhabdoviruses Part 4. 1st International Symposium on Bovine Ephemeral Fever and Related Rhabdoviruses, Beijing, China, (131-137). 25-27 August 1992.

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Author Cybinski, D. H.
St George, T. D.
Title of paper Antigenic variation in the bovine ephemeral fever virus glycoprotein
Conference name 1st International Symposium on Bovine Ephemeral Fever and Related Rhabdoviruses
Conference location Beijing, China
Conference dates 25-27 August 1992
Proceedings title Bovine Ephemeral Fever and Related Rhabdoviruses Part 4
Series ACIAR Proceedings
Place of Publication Canberra, Australia
Publisher Australian Centre for International Agricultural Research
Publication Year 1993
Sub-type Fully published paper
Editor T. D. St George
M. F. Uren
P. L. Young
D. Hoffmann
Volume 44
Start page 131
End page 137
Total pages 7
Language eng
Abstract/Summary Antigenic variation in the bovine ephemeral fever virus glycoprotein was demonstrated using monoclonal antibodies and comparing a particular passage level of the BB7721 strain with (1) other Australian isolates of BEF virus, (2) the Beijing 1 strain of BEF virus, isolated in China and (3) batches of the BB7721 strain with different passage histories. Escape mutants of BEF virus were selected from cell culture and suckling mice, by growing virus in the presence of neutralising monoclonal antibodies. Escape frequencies were calculated for 14 monoclonal antibodies and an epitope map constructed of antigenic sites on the BEF viral glycoprotein which induce the production of neutralising antibodies.
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: Toby Dix St George Publications
 
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