Complex cocktails: the evolutionary novelty of venoms

Casewell, Nicholas R., Wuster, Wolfgang, Vonk, Freek J., Harrison, Robert A. and Fry, Bryan G. (2012) Complex cocktails: the evolutionary novelty of venoms. Trends In Ecology & Evolution, 28 4: 219-229. doi:10.1016/j.tree.2012.10.020

Author Casewell, Nicholas R.
Wuster, Wolfgang
Vonk, Freek J.
Harrison, Robert A.
Fry, Bryan G.
Total Author Count Override 5
Title Complex cocktails: the evolutionary novelty of venoms
Journal name Trends In Ecology & Evolution   Check publisher's open access policy
ISSN 0169-5347
Publication date 2012-12-05
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tree.2012.10.020
Volume 28
Issue 4
Start page 219
End page 229
Total pages 11
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2013
Language eng
Abstract Venoms have evolved on numerous occasions throughout the animal kingdom. These 'biochemical weapon systems' typically function to facilitate, or protect the producing animal from, predation. Most venomous animals remain unstudied despite venoms providing model systems for investigating predator-prey interactions, molecular evolution, functional convergence, and novel targets for pharmaceutical discovery. Through advances in 'omic' technologies, venom composition data have recently become available for several venomous lineages, revealing considerable complexity in the processes responsible for generating the genetic and functional diversity observed in many venoms. Here, we review these recent advances and highlight the ecological and evolutionary novelty of venom systems.
Keyword Antivenom
Drug discovery
Gene duplication
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 5 December 2012.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Biological Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 109 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 115 times in Scopus Article | Citations
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Created: Sat, 02 Feb 2013, 11:16:16 EST by Gail Walter on behalf of School of Biological Sciences