Acute elevation of lipids does not alter exercise hemodynamics in healthy men: a randomized controlled study

Sharman, James E., Holland, David J., Leano, Rodel and Kostner, Karam M. (2013) Acute elevation of lipids does not alter exercise hemodynamics in healthy men: a randomized controlled study. Atherosclerosis, 226 1: 234-237. doi:10.1016/j.atherosclerosis.2012.10.047


Author Sharman, James E.
Holland, David J.
Leano, Rodel
Kostner, Karam M.
Title Acute elevation of lipids does not alter exercise hemodynamics in healthy men: a randomized controlled study
Journal name Atherosclerosis   Check publisher's open access policy
ISSN 0021-9150
1879-1484
Publication date 2013-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.atherosclerosis.2012.10.047
Volume 226
Issue 1
Start page 234
End page 237
Total pages 4
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Collection year 2013
Language eng
Formatted abstract
Objective: Exaggerated exercise blood pressure (BP) predicts mortality. Some studies suggest this could be explained by chronic hyperlipidemia, but whether acute-hyperlipidemia effects exercise BP has never been tested, and was the aim of this study.

Methods: Intravenous infusion of saline (control) and Intralipid were administered over 60 min in 15 healthy men by double-blind, randomized, cross-over design. Brachial and central BP (including, pulse pressure, augmentation pressure and augmentation index), cardiac output and systemic vascular resistance were recorded at rest and during exercise.

Results: Compared with control, Intralipid caused significant increases in serum triglycerides, very low density lipoproteins and free fatty acids (p < 0.001 for all). However, there was no significant difference for any exercise hemodynamic variable (p > 0.05 for all).

Conclusion: Acute-hyperlipidemia does not significantly change exercise hemodynamics in healthy males. Therefore, the association between raised lipids and increased exercise BP is likely due to the chronic effects of hyperlipidemia.
Keyword Cholesterol
Hemodynamics
Aorta
Physical activity
Hypertension
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 26 October 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
 
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