Primary sensory and motor cortex excitability are co-modulated in response to peripheral electrical nerve stimulation

Schabrun, Siobhan M., Ridding, Michael C., Galea, Mary P., Hodges, Paul W. and Chipchase, Lucinda S. (2012) Primary sensory and motor cortex excitability are co-modulated in response to peripheral electrical nerve stimulation. PLoS One, 7 12 Article. No.e51298: 51298-1-51298-7. doi:10.1371/journal.pone.0051298


Author Schabrun, Siobhan M.
Ridding, Michael C.
Galea, Mary P.
Hodges, Paul W.
Chipchase, Lucinda S.
Title Primary sensory and motor cortex excitability are co-modulated in response to peripheral electrical nerve stimulation
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2012-12
Sub-type Article (original research)
DOI 10.1371/journal.pone.0051298
Open Access Status DOI
Volume 7
Issue 12 Article. No.e51298
Start page 51298-1
End page 51298-7
Total pages 7
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2013
Language eng
Formatted abstract
Peripheral electrical stimulation (PES) is a common clinical technique known to induce changes in corticomotor excitability; PES applied to induce a tetanic motor contraction increases, and PES at sub-motor threshold (sensory) intensities decreases, corticomotor excitability. Understanding of the mechanisms underlying these opposite changes in corticomotor excitability remains elusive. Modulation of primary sensory cortex (S1) excitability could underlie altered corticomotor excitability with PES. Here we examined whether changes in primary sensory (S1) and motor (M1) cortex excitability follow the same time-course when PES is applied using identical stimulus parameters. Corticomotor excitability was measured using transcranial magnetic stimulation (TMS) and sensory cortex excitability using somatosensory evoked potentials (SEPs) before and after 30 min of PES to right abductor pollicis brevis (APB). Two PES paradigms were tested in separate sessions; PES sufficient to induce a tetanic motor contraction (30-50 Hz; strong motor intensity) and PES at sub motor-threshold intensity (100 Hz). PES applied to induce strong activation of APB increased the size of the N20-P25 component, thought to reflect sensory processing at cortical level, and increased corticomotor excitability. PES at sensory intensity decreased the size of the P25-N33 component and reduced corticomotor excitability. A positive correlation was observed between the changes in amplitude of the cortical SEP components and corticomotor excitability following sensory and motor PES. Sensory PES also increased the sub-cortical P14-N20 SEP component. These findings provide evidence that PES results in co-modulation of S1 and M1 excitability, possibly due to cortico-cortical projections between S1 and M1. This mechanism may underpin changes in corticomotor excitability in response to afferent input generated by PES.
Keyword Transcranial Magnetic Stimulation
Somatosensory Evoked-Potentials
System Amplification
Functional roles
Plasticity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
School of Health and Rehabilitation Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 24 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 27 Jan 2013, 00:32:01 EST by System User on behalf of UQ Centre for Clinical Research