A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Al Olama, Ali Amin, Kote-Jarai, Zsofia, Schumacher, Fredrick R., Wiklund, Fredrik, Berndt, Sonja I., Benlloch, Sara, Giles, Graham G., Severi, Gianluca, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Hunter, David J., Henderson, Brian E., Thun, Michael J., Gaziano, Michael, Giovannucci, Edward L., Siddiq, Afshan, Travis, Ruth C., Cox, David G., Canzian, Federico, Riboli, Elio, Key, Timothy J., Andriole, Gerald, Albanes, Demetrius, Hayes, Richard B., Schleutker, Johanna, Auvinen, Anssi, Tammela, Teuvo L. J., Weischer, Maren, Stanford, Janet L., Ostrander, Elaine A., Cybulski, Cezary, Lubinski, Jan, Thibodeau, Stephen N., Schaid, Daniel J., Sorensen, Karina D., Batra, Jyotsna, Clements, Judith A., Chambers, Suzanne, Aitken, Joanne, Gardiner, Robert A., Maier, Christiane, Vogel, Walther, Doerk, Thilo, Brenner, Hermann, Habuchi, Tomonori, Ingles, Sue, John, Esther M., Dickinson, Joanne L., Cannon-Albright, Lisa, Teixeira, Manuel R., Kaneva, Radka, Zhang, Hong-Wei, Lu, Yong-Jie, Park, Jong Y., Cooney, Kathleen A., Muir, Kenneth R., Leongamornlert, Daniel A., Saunders, Edward, Tymrakiewicz, Malgorzata, Mahmud, Nadiya, Guy, Michelle, Govindasami, Koveela, O'Brien, Lynne T., Wilkinson, Rosemary A., Hall, Amanda L., Sawyer, Emma J., Dadaev, Tokhir, Morrison, Jonathan, Dearnaley, David P., Horwich, Alan, Huddart, Robert A., Khoo, Vincent S., Parker, Christopher C., Van As, Nicholas, Woodhouse, Christopher J., Thompson, Alan, Dudderidge, Tim, Ogden, Chris, Cooper, Colin S., Lophatonanon, Artitaya, Southey, Melissa C., Hopper, John L., English, Dallas, Virtamo, Jarmo, Le Marchand, Loic, Campa, Daniele, Kaaks, Rudolf, Lindstrom, Sara, Diver, W. Ryan, Gapstur, Susan, Yeager, Meredith, Cox, Angela, Stern, Mariana C., Corral, Roman, Aly, Markus, Isaacs, William, Adolfsson, Jan, Xu, Jianfeng, Zheng, S. Lilly, Wahlfors, Tiina, Taari, Kimmo, Kujala, Paula, Klarskov, Peter, Nordestgaard, Borge G., Roder, M. Andreas, Frikke-Schmidt, Ruth, Bojesen, Stig E., FitzGerald, Liesel M., Kolb, Suzanne, Kwon, Erika M., Karyadi, Danielle M., Orntoft, Torben Falck, Borre, Michael, Rinckleb, Antje, Luedeke, Manuel, Herkommer, Kathleen, Meyer, Andreas, Serth, Juergen, Marthick, James R., Patterson, Briony, Wokolorczyk, Dominika, Spurdle, Amanda, Lose, Felicity, McDonnell, Shannon K., Joshi, Amit D., Shahabi, Ahva, Pinto, Pedro, Santos, Joana, Ray, Ana, Sellers, Thomas A., Lin, Hui-Yi, Stephenson, Robert A., Teerlink, Craig, Muller, Heiko, Rothenbacher, Dietrich, Tsuchiya, Norihiko, Narita, Shintaro, Cao, Guang-Wen, Slavov, Chavdar, Mitev, Vanio, Chanock, Stephen, Gronberg, Henrik, Haiman, Christopher A., Kraft, Peter, Easton, Douglas F. and Eeles, Rosalind A. (2013) A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Human Molecular Genetics, 22 2: 408-415. doi:10.1093/hmg/dds425

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Author Al Olama, Ali Amin
Kote-Jarai, Zsofia
Schumacher, Fredrick R.
Wiklund, Fredrik
Berndt, Sonja I.
Benlloch, Sara
Giles, Graham G.
Severi, Gianluca
Neal, David E.
Hamdy, Freddie C.
Donovan, Jenny L.
Hunter, David J.
Henderson, Brian E.
Thun, Michael J.
Gaziano, Michael
Giovannucci, Edward L.
Siddiq, Afshan
Travis, Ruth C.
Cox, David G.
Canzian, Federico
Riboli, Elio
Key, Timothy J.
Andriole, Gerald
Albanes, Demetrius
Hayes, Richard B.
Schleutker, Johanna
Auvinen, Anssi
Tammela, Teuvo L. J.
Weischer, Maren
Stanford, Janet L.
Ostrander, Elaine A.
Cybulski, Cezary
Lubinski, Jan
Thibodeau, Stephen N.
Schaid, Daniel J.
Sorensen, Karina D.
Batra, Jyotsna
Clements, Judith A.
Chambers, Suzanne
Aitken, Joanne
Gardiner, Robert A.
Maier, Christiane
Vogel, Walther
Doerk, Thilo
Brenner, Hermann
Habuchi, Tomonori
Ingles, Sue
John, Esther M.
Dickinson, Joanne L.
Cannon-Albright, Lisa
Teixeira, Manuel R.
Kaneva, Radka
Zhang, Hong-Wei
Lu, Yong-Jie
Park, Jong Y.
Cooney, Kathleen A.
Muir, Kenneth R.
Leongamornlert, Daniel A.
Saunders, Edward
Tymrakiewicz, Malgorzata
Mahmud, Nadiya
Guy, Michelle
Govindasami, Koveela
O'Brien, Lynne T.
Wilkinson, Rosemary A.
Hall, Amanda L.
Sawyer, Emma J.
Dadaev, Tokhir
Morrison, Jonathan
Dearnaley, David P.
Horwich, Alan
Huddart, Robert A.
Khoo, Vincent S.
Parker, Christopher C.
Van As, Nicholas
Woodhouse, Christopher J.
Thompson, Alan
Dudderidge, Tim
Ogden, Chris
Cooper, Colin S.
Lophatonanon, Artitaya
Southey, Melissa C.
Hopper, John L.
English, Dallas
Virtamo, Jarmo
Le Marchand, Loic
Campa, Daniele
Kaaks, Rudolf
Lindstrom, Sara
Diver, W. Ryan
Gapstur, Susan
Yeager, Meredith
Cox, Angela
Stern, Mariana C.
Corral, Roman
Aly, Markus
Isaacs, William
Adolfsson, Jan
Xu, Jianfeng
Zheng, S. Lilly
Wahlfors, Tiina
Taari, Kimmo
Kujala, Paula
Klarskov, Peter
Nordestgaard, Borge G.
Roder, M. Andreas
Frikke-Schmidt, Ruth
Bojesen, Stig E.
FitzGerald, Liesel M.
Kolb, Suzanne
Kwon, Erika M.
Karyadi, Danielle M.
Orntoft, Torben Falck
Borre, Michael
Rinckleb, Antje
Luedeke, Manuel
Herkommer, Kathleen
Meyer, Andreas
Serth, Juergen
Marthick, James R.
Patterson, Briony
Wokolorczyk, Dominika
Spurdle, Amanda
Lose, Felicity
McDonnell, Shannon K.
Joshi, Amit D.
Shahabi, Ahva
Pinto, Pedro
Santos, Joana
Ray, Ana
Sellers, Thomas A.
Lin, Hui-Yi
Stephenson, Robert A.
Teerlink, Craig
Muller, Heiko
Rothenbacher, Dietrich
Tsuchiya, Norihiko
Narita, Shintaro
Cao, Guang-Wen
Slavov, Chavdar
Mitev, Vanio
Chanock, Stephen
Gronberg, Henrik
Haiman, Christopher A.
Kraft, Peter
Easton, Douglas F.
Eeles, Rosalind A.
Total Author Count Override 274
Title A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease
Journal name Human Molecular Genetics   Check publisher's open access policy
ISSN 0964-6906
1460-2083
Publication date 2013-01
Year available 2012
Sub-type Article (original research)
DOI 10.1093/hmg/dds425
Volume 22
Issue 2
Start page 408
End page 415
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2013
Language eng
Formatted abstract
Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significantSNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10-8]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.
Keyword Genes
Expression
Variants
Prostate cancer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First published online: 12 October 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
School of Medicine Publications
 
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