Cadherin junctions and their cytoskeleton(s)

Brieher, William M. and Yap, Alpha S. (2013) Cadherin junctions and their cytoskeleton(s). Current Opinion in Cell Biology, 25 1: 39-46. doi:10.1016/

Author Brieher, William M.
Yap, Alpha S.
Title Cadherin junctions and their cytoskeleton(s)
Journal name Current Opinion in Cell Biology   Check publisher's open access policy
ISSN 0955-0674
Publication date 2013-02
Year available 2012
Sub-type Article (original research)
DOI 10.1016/
Volume 25
Issue 1
Start page 39
End page 46
Total pages 8
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2013
Language eng
Abstract Classical cadherin adhesion receptors exert many of their biological effects through close cooperation with the cytoskeleton. Much attention has focused on attempting to understand the physical interactions between cadherin molecular complexes and cortical actin filaments. In this review we aim to draw attention to other issues that highlight the diverse and dynamic cytoskeletons that contribute to cadherin function. First, we discuss the regulation of actin filament dynamics in the cadherin-based junctional cytoskeleton, focusing on the emerging role of Arp2/3 as a junctional actin nucleator and its implications for actin homeostasis at junctions. Second, we review recent developments in understanding the impact of microtubules on cadherin function. Together, these emphasize that cadherins cooperate with multiple dynamic cytoskeletal networks at cell–cell junctions.
Keyword Cell-cell contacts
Epithelial zonula adherens
Cytokinetic contractile ring
Budding yeast cytokinesis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 2 November 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 49 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
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Created: Mon, 21 Jan 2013, 14:13:19 EST by Susan Allen on behalf of Institute for Molecular Bioscience