High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover

Neller, M. A., Burrows, J. M., Rist, M. J., Miles, J. J. and Burrows, S. R. (2013) High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover. Journal of Virology, 87 1: 697-700. doi:10.1128/JVI.02180-12


Author Neller, M. A.
Burrows, J. M.
Rist, M. J.
Miles, J. J.
Burrows, S. R.
Title High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 2013-01
Year available 2012
Sub-type Article (original research)
DOI 10.1128/JVI.02180-12
Open Access Status DOI
Volume 87
Issue 1
Start page 697
End page 700
Total pages 4
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2013
Language eng
Abstract High-throughput T cell receptor sequencing on sequentially banked blood samples from healthy individuals has shown that high-frequency clonotypes can remain relatively stable for up to 18 years, with minimal inflation, deflation, or turnover. These populations included T cell expansions specific for Epstein-Barr virus. Thus, in spite of exposure to a barrage of microorganisms over the course of life, the dominant clonotypes in the mature peripheral T cell repertoire can alter surprisingly little.
Keyword Viral infection
Cytomegalovirus
Virus
T cell
Clonotypes
Epstein-Barr
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 17 October 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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